نتایج جستجو برای: and ns5a proteins

تعداد نتایج: 16874701  

Journal: :The Journal of general virology 2006
Shuanghu Liu Israrul H Ansari Subash C Das Asit K Pattnaik

Hepatitis C virus (HCV) non-structural protein 5A (NS5A) plays an essential role in viral genome replication. A series of transposon-mediated insertion mutants and deletion mutants of NS5A was used to examine the colony-forming ability of HCV subgenomic replicons encoding the mutant proteins. The results reveal that two regions of NS5A can tolerate insertions: one spanning residues 240-314, whi...

Journal: :Journal of virology 2013
Qingxia Han David Manna Kerry Belton Richard Cole Kouacou V Konan

Hepatitis C Virus (HCV) NS4B protein has many roles in HCV genome replication. Recently, our laboratory (Q. Han, J. Aligo, D. Manna, K. Belton, S. V. Chintapalli, Y. Hong, R. L. Patterson, D. B. van Rossum, and K. V. Konan, J. Virol. 85:6464-6479, 2011) and others (D. M. Jones, A. H. Patel, P. Targett-Adams, and J. McLauchlan, J. Virol. 83:2163-2177, 2009; D. Paul, I. Romero-Brey, J. Gouttenoir...

2012
Garvita Gupta Haina Qin Jianxing Song

Hepatitis C virus (HCV) affects nearly 200 million people worldwide and is a leading factor for serious chronic liver diseases. For replicating HCV genome, the membrane-associated replication machinery needs to be formed by both HCV non-structural proteins including NS5A and human host factors. Recently NS5A has been identified to bind ER-anchored human VAP proteins and consequently this intera...

Journal: :Journal of virology 2008
Shuhei Taguwa Toru Okamoto Takayuki Abe Yoshio Mori Tetsuro Suzuki Kohji Moriishi Yoshiharu Matsuura

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is required for the replication of the viral genome and is involved in several host signaling pathways. To gain further insight into the functional role of NS5A in HCV replication, we screened human cDNA libraries by a yeast two-hybrid system using NS5A as the bait and identified human butyrate-induced transcript 1 (hB-ind1) as a novel NS5...

Journal: :The Journal of biological chemistry 2013
Gregory Camus Eva Herker Ankit A Modi Joel T Haas Holly R Ramage Robert V Farese Melanie Ott

The triglyceride-synthesizing enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) plays a critical role in hepatitis C virus (HCV) infection by recruiting the HCV capsid protein core onto the surface of cellular lipid droplets (LDs). Here we find a new interaction between the non-structural protein NS5A and DGAT1 and show that the trafficking of NS5A to LDs depends on DGAT1 activity. DGAT1...

Journal: :Journal of virology 1997
S I Asabe Y Tanji S Satoh T Kaneko K Kimura K Shimotohno

We previously showed that two proteins, a 56-kDa protein (p56) and a 58-kDa protein (p58), are produced from the hepatitis C virus (HCV) nonstructural 5A region (NS5A) and that the production of p58 is enhanced by the presence of NS4A (T. Kaneko, Y. Tanji, S. Satoh, M. Hijikata, S. Asabe, K. Kimura, and K. Shimotohno, Biochem. Biophys. Res. Commun. 205:320-326, 1994). Both proteins have phospho...

2015
Zsofia Igloi Arunas Kazlauskas Kalle Saksela Andrew Macdonald Jamel Mankouri Mark Harris

Hepatitis C virus (HCV) establishes a persistent infection that in many cases leads to cirrhosis and hepatocellular carcinoma. The non-structural 5A protein (NS5A) has been implicated in this process as it contains a C-terminal polyproline motif (termed P2) that binds to Src homology 3 (SH3) domains to regulate cellular signalling and trafficking pathways. We have shown previously that NS5A imp...

Journal: :Antimicrobial agents and chemotherapy 2015
Donald R O'Boyle Peter T Nower Min Gao Robert Fridell Chunfu Wang Piyasena Hewawasam Omar Lopez Yong Tu Nicholas A Meanwell Makonen Belema Susan B Roberts Mark Cockett Jin-Hua Sun

Daclatasvir (DCV) is a first-in-class hepatitis C virus (HCV) nonstructural 5A replication complex inhibitor (NS5A RCI) that is clinically effective in interferon-free combinations with direct-acting antivirals (DAAs) targeting alternate HCV proteins. Recently, we reported NS5A RCI combinations that enhance HCV inhibitory potential in vitro, defining a new class of HCV inhibitors termed NS5A sy...

Journal: :The Journal of biological chemistry 2005
Luyun Huang Jungwook Hwang Suresh D Sharma Michele R S Hargittai Yingfeng Chen Jamie J Arnold Kevin D Raney Craig E Cameron

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) has been shown to antagonize numerous cellular pathways, including the antiviral interferon-alpha response. However, the capacity of this protein to interact with the viral polymerase suggests a more direct role for NS5A in genome replication. In this study, we employed two bacterially expressed, soluble derivatives of NS5A to probe for no...

Journal: :The EMBO journal 2006
Toru Okamoto Yorihiro Nishimura Tohru Ichimura Kensuke Suzuki Tatsuo Miyamura Tetsuro Suzuki Kohji Moriishi Yoshiharu Matsuura

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a component of viral replicase and is well known to modulate the functions of several host proteins. Here, we show that NS5A specifically interacts with FKBP8, a member of the FK506-binding protein family, but not with other homologous immunophilins. Three sets of tetratricopeptide repeats in FKBP8 are responsible for interactions with ...

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