BACKGROUND Contact allergy to local anaesthetics is relatively common. Patch testing with benzocaine in the European baseline series is recommended for diagnosis, even though a caine mix has been previously suggested to be superior. OBJECTIVES To assess the frequency and patterns of contact allergy to local anaesthetics by using a caine mix (benzocaine, tetracaine, and cinchocaine) in the bas...

General anaesthetics are a large group of physiologically active substances which, although structurally diverse, are generally regarded as possessing one common physical-chemical property—a high solubility in hydrophobic solvents. Clinically, general anaesthetics have the well known and very useful properties of being able to abolish sensation and to produce unconsciousness, and are thus used ...

Local anaesthetics have been used clinically for well over a century, but the molecular mechanisms by which they alter speci®c functions of the peripheral nerve system remained unclear for a long time. Investigations during the last few decades presented evidence implicating the sodium (Na) channel protein as a target for speci®c, clinically important, local anaesthetic effects on mammalian neu...

The present study aimed to determine the optimal concentration of three anaesthetics, name MS222, ketamine, and tobacco extract, in grass carp juveniles (107.78±22.11 g body weight and 226.74±13.06 mm total body length). Treatments were as follows: 100 mg L-1 of MS222 (control group), 5.5, 8, 11, 18.5, and 22 mg L-1 of ketamine, and 10, 13.33, 20, 26.27, and 40 mg L-1 of tobacco extract. In add...

REZUMAT Correspondence to: REVIEW ARTICLES CARDIOPROTECTION BY VOLATILE ANAESTHETICS: ANAESTHETIC-INDUCED PRECONDITIONING Octavian Toma, Wolfgang Schlack Precondi]ionarea anestezic\ a miocardului este un fenomen bine precizat prin care anestezicele volatile induc un efect cardioprotectiv care persist\ un anumit timp dup\ întreruperea anestezicului. Anestezicele volatile reduc necroza/apoptoza m...

Local anaesthetics, cinchocaine and amethocaine, inhibited superoxide production in human neutrophils stimulated by phorbol ester, with IC50 (concentration of a drug giving 50% activity of control) values of 0.2 and 0.6 mmol litre-1, respectively. These anaesthetics inhibited protein (de)phosphorylation and mobilization of membrane-associated calcium, both of which are probable signal transmiss...