UNLABELLED The aim of the study was to verify by Ki-67 immunostaining if any difference exists in the cell proliferating fraction between primary breast tumors (PTs) and matching positive axillary lymph nodes (ALNs). PATIENTS AND METHODS Immunohistochemistry with the monoclonal antibody against Ki-67 was performed in 160 node-positive breast carcinomas and in their respective lymph node metas...

While much research has shown that ALNs can produce learning equivalent to FTF classrooms, there has been little empirical research that explicitly and rigorously explores similarities and differences between the learning processes that occur in ALN and FTF activities. Transcripts from eight case study discussions, 4 FTF, 4 ALN, were content analyzed. The study used a content analytic framework...

Unmanned air vehicles (UAVs) have been regularly employed in modern wars to conduct different missions. Instead of addressing mission planning and route separately, this study investigates the issue joint for a fleet UAVs. The determines configuration weapons UAVs attack targets, while UAV's visiting sequence targets. problem is formulated as an integer linear programming model. Due inefficienc...

Discrimination of stance and swing phases of the gait is required for control of functional e!ectrical stimulation (FES) used to assist with ankle dorsiflexion in foot-drop problem. Simple thresholds applied to a human, whole nerve signal processed using a sophisticated digital signal processing technique did not result in a safe and reliable control method. In this preliminary study, we use th...

PURPOSE Hypermethylation of the tumor suppressor genes is frequently observed in the tumor development and progression. However, the correlation between the hypermethylation of the tumor suppressor genes, CDH1 and the axillary lymph node (ALN) metastasis is not fully elucidated. To verify the role of the CDH1 promoter hypermethylation in the ALN metastasis and prognosis, we compared the methyla...

In the different stages of the educational system, the demand for efficient planning is increasing. This article treats theNP-hardConsultation Timetabling Problem, a recurrent planning problem for the high schools in Denmark, which has not been described in the literature before. Two versions of the problem are considered, the Parental Consultation Timetabling Problem (PCTP) and the Supervisor ...

Distance education via asynchronous learning networks (ALNs) is an increasingly common method of educational delivery. To add to a practical and academic understanding of asynchronous, computer-mediated communication this article reports a conversation analysis study to „map the ground‟ of ALNs by identifying and describing conversation practices of ALN students in terms of conversation analyti...

The Pickup and Delivery Problem with Time Windows and Scheduled Lines (PDPTW-SL) concerns scheduling a set of vehicles to serve freight requests such that a part of the journey can be carried out on a scheduled public transportation line using bus, train, tram, metro, etc. Due to the complexity of the problem, which is NP-hard, we propose an Adaptive Large Neighborhood Search (ALNS) heuristic a...

Many problem-specific heuristic frameworks have been developed to solve combinatorial optimization problems, but these do not generalize well other problem domains. Metaheuristic aim be more generalizable compared traditional heuristics, however their performances suffer from poor selection of low-level heuristics (operators) during the search process. An example in a metaheuristic framework is...

<p style='text-indent:20px;'>In considering route optimization from multiple distribution centers called depots via some intermediate facilities satellites to final customers with commodities request, we introduce the Multi-Commodity Two-Echelon Vehicle Routing Problem Satellite Synchronization (MC-2E-VRPSS). The MC-2E-VRPSS involves transportation on first echelon and deliveries second e...