AIMS The long-term cardioprotective effect of angiotensin receptor blockers (ARBs) is associated with the short-term lowering of its primary target blood pressure, but also with the lowering of albuminuria. Since the individual blood pressure and albuminuria response to an ARB varies between and within an individual, we tested whether the variability and discordance in systolic blood pressure (...

Assess the relationship and diagnostic performance of retinol-binding protein 4 (RBP-4) as a biomarker ofdiabetic nephropathy (DN) at different levels albuminuria (normo-, micro- macro-albuminuria). Acase-control study, that involved 185 participants, 47 were healthy control, 138 diabetic patients (46were normoalbuminuric [NA], 48 microalbuminuria [MiA], 44 weremacroalbuminuria [MaA]). All trea...

OBJECTIVES To compare a less cumbersome random albumin creatinine ratio (RACR) with 24-hour urinary albumin excretion (UAE) for detection of renal damage in patients with type 2 diabetes mellitus (T2DM). METHODS This retrospective study performed between March 2013 and June 2014 at the Department of Pathology, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia included 122 patie...

AIMS To replicate the association of genetic variants with estimated glomerular filtration rate (GFR) and albuminuria, which has been found in recent genome-wide studies in patients with Type 2 diabetes. METHODS We evaluated 16 candidate single nucleotide polymorphisms for estimated GFR in 3028 patients with Type 2 diabetes sampled from clinics across Tayside, Scotland, UK, who were included ...

Abstract Background and Aims Chronic kidney disease (CKD) its associated complications constitute a major challenge for healthcare systems worldwide. Albuminuria, measured as albumin-to-creatinine ratio (uACR), is critical marker of glomerular injury endothelial dysfunction. Elevated uACR an independent predictor CKD progression cardio-renal mortality [1,2]. However, there paucity data translat...

Albuminuria is a risk factor strongly associated with cardiovascular disease, the first cause of death in the general population. It is well established that renin-angiotensin system suppressors prevent the development of new-onset albuminuria in naïf hypertensive patients and diminish its excretion, but we cannot forget the percentage of hypertensive patients who develop de novo albuminuria. H...

OBJECTIVE The objective of this study was to determine whether high levels of HDL cholesterol are associated with a lower prevalence of albuminuria RESEARCH DESIGN AND METHODS We analyzed the lipid profiles of patients with type 1 diabetes of > or = 20 years duration in 42 patients with albuminuria (28 microalbuminuria and 14 macroalbuminuria) and 65 patients without increased albumin excreti...

BACKGROUND Albuminuria is a risk factor for not only nephropathy progression but also cardiovascular disease. Oxidative stress may have a role in the positive association between albuminuria and cardiovascular disease. METHODS This cross-sectional study investigated the associations of serum levels of carotenoids, which are dietary antioxidants, with albuminuria among 501 Japanese adults (198...