The present study deals with the effect of herbal powder of Vernonia cinerea and Cuminum cyminum on tissue defense system against CCl4 (carbon tetrachloride) induced hepatic injury in rats. CCl4 diluted with liquid paraffin oil (1:1 ratio) in a dose of 1ml / kg body wt was given intraperitoneally for 2 days. Herbal powder as a suspension of water (10mg / 100g body wt / day) was administered ora...

Acute rhabdomyolysis and elevated transaminases during streptococcal pharyngitis are rare presentations. The proposed pathophysiological mechanisms include direct bacterial invasion toxin generation. Physicians should be aware of the association between these infections above-mentioned complications to facilitate optimal treatment patients. We present case a 18-years-old gentleman with β-haemol...

It has been reported that growth hormone (GH)-releasing peptide-2 (GHRP-2), a ghrelin receptor agonist, has an anti-inflammatory effect. We investigated whether this GH secretagogue attenuates liver injury in LPS-treated rats. Wistar rats were simultaneously injected (ip) with LPS (1 mg/kg) and/or GHRP-2 (100 microg/kg). Serum levels of aspartate and alanine transaminases were measured as an in...

A short-term study was conducted after the oil spillage from the tanker Tasman Spirit to analyse seawater and sand samples taken from Karachi beach for hydrocarbon/organic contents. Blood samples were collected from people who were working or living in the vicinity of the beach. Lymphocyte and eosinophil levels were slightly increased. About 11 people had raised serum glutamic pyruvic transamin...

BACKGROUND Chronic ethanol administration to rodents requires specially designed equipment and is labor intensive. Here we report a new procedure. METHOD A commercial liquid diet preparation was made into a gel by addition of 0.5% agar. The gel, containing 5.3% ethanol, was offered in Falcon tubes equipped with a feeding opening. RESULTS The gel consumption by C57/Bl mice resulted in high b...

       The anti-apoptotic gene bcl-2 is located in mitochondria, but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion (I/R) injury. This experiment was designed to evaluate the role of folic acid in expression of bcl-2 in I/R in rat liver. Eighteen Wister rats were divided into sham-operated controlgroup (C) (n=6), I/R group (...

OBJECTIVE To characterize a chronic hepatitis B cohort based on initial and follow-up clinical evaluations. METHODS A retrospective and descriptive analysis of clinical and laboratory data from chronic HBsAg adult carriers, without HIV, unexposed to treatment, with at least two outpatient visits, between February 2006 and November 2012. Fisher´s exact test, χ², Wilcoxon, Spearman, multiple co...

The aqueous extract of leaves of Parkia biglobosa (Pb) is used in Africa to cure hypertension or for the treatment of immunocompromised individuals. To avoid intoxication of consumers, our study was carried out to evaluate the action of the extract on the level of glucose and liver enzymes [Akaline phosphatase (ALP), Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT)]. Two sets...

The aim of this study was to investigate the causes of elevated levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in children. We analyzed the medical records for children aged 3 months to 18 years who presented to the hospital with ALT >45 IU/L and/or AST >50 IU/L, between 2012 and 2014, for various reasons, including those not related to liver disease. In total, 28...