Platelet survival time and platelet adhesiveness and aggregation were examined in 16 patients with prosthetic mitral valves. Subsequently, nine patients were treated with sulfinpyrazone in doses of 400 mg and 800 mg/day, and the studies were repeated after a treatment period of 5 to 8 weeks. 51Chromium survival time was shortened in 15 of 16 patients, and the mean value for the entire group was...

PURPOSE Normal retina is firmly attached to the retinal pigment epithelium, but the force of this adhesion drops precipitously within the first 2-3 min after enucleation. The purpose was to study metabolic factors that might be relevant to this postmortem failure of adhesion. METHODS Dutch rabbit retina was manually peeled from the retinal pigment epithelium on strips of enucleated eyecup wit...

BACKGROUND Chronic elevation of glucose level activates vascular inflammation and increases endothelial adhesiveness to monocytes, an early sign of atherogenesis. This study aimed to elucidate the detailed mechanisms of high-glucose-induced endothelial inflammation, and to investigate the potential effects of Ginkgo biloba extract (GBE), an antioxidant herbal medicine, on such inflammation. M...

The nature of vascular disease and its complications are different in juvenile-onset (JOD) and maturity-onset (MOD) diabetes mellitus. In order to explore the disturbances in the coagulation-fibrinolytic system, platelet adhesiveness, plasma fibrinogen, and euglobulin lysis time were estimated in 26 cases of MOD. Two groups of age- and sex-matched controls were also studied. Platelet adhesivene...

Platelet adhesiveness to glass beads was measured in citrated blood at intervals up to two hours after the addition of adenosine diphosphate (A.D.P.). Adhesiveness increased for 15 minutes, fell towards the original level, and then steadily increased. The initial changes were associated with the formation and subsequent dispersal of platelet clumps. The sequence of events resembled the reported...

By J. PHILIP SAVITSKY, M.D. C HANGES in platelet adhesivemiess have been noted during the course of many different clinical conditions.t4 Imicreased platelet adhesiveness has been correlated by some investigators with a predisposition to thromboembolic phemiomena and vascular disease,2 but other work has not confirmed this suiggestion.3 It has been show’mi that there is a very close relation be...