OBJECTIVE To review the use of systemic corticosteroids to treat recurrent, acute asthma episodes in children, with a focus on the role of oral corticosteroids. METHODS A comprehensive review of the literature was performed using the Medline database (January 1966-October 2002) and the Embase database (January 1980-August 2002). RESULTS The significant findings of 17 selected, controlled cl...

Chlamydia pneumoniae (Cpn) could have three distinguishable causal effects as an asthma inducer. First, an acute infection (or reactivation of a latent infection) could cause an acute worsening of preexisting asthma. Indeed, it is generally accepted that acute Cpn infection can cause some acute asthma exacnhations('~*) but most evidence suggests that other organisms [mainly respiratory viruses,...

Asthma prevalence and mortality have been increasing over the past 2 decades, despite advances in medical therapy. In 2003 the National Health Interview Survey reported over 4,000 asthma-related deaths. A small proportion of people with severe asthma use a large proportion of health-care resources and bear the burden of asthma-related morbidity and mortality. The management of acute asthma is c...

The incidence of anaphylaxis is under-reported. Children with asthma are frequently atopic and prone to allergic reactions. Parents and clinicians may attribute wheeze of rapid onset to acute severe asthma, rather than recognising an anaphylactic event. Two cases of fatal anaphylaxis are reported who were initially diagnosed as acute severe asthma, and responded poorly to bronchodilator treatme...

asthma is one of the most common acute and chronic conditions in children, and the pediatricians are expected to provide an important role for asthma care in this age group, however there is no published information describing the different aspects of their practices about children asthma in iran. this study was done to characterize the knowledge of the iranian pediatricians about the diagnosis...

Emerging evidence suggests an association between some asthma and pulmonary infection by the atypical organisms Chlamydia pneumoniae and Mycoplasma pneumoniae, but a causal role for infection remains unproven and controversial. Most acute exacerbations of asthma are triggered by acute infections that are due to viral respiratory pathogens, not to bacteria or atypical organisms. Administration o...

corticosteroids are recommended for emergency management of an asthmatic attack. this study was designed to compare the effectiveness of oral and intramuscular steroid on spirometric results in acute asthma. we performed a randomized trial involving 88 adults, aged 15-70 years, with acute exacerbation of asthma requiring treatment with steroids. all had been treated with standard bronchodilator...

To clarify clinical significance of high mobility group box 1 level in inflammation asthma-chronic obstructive pulmonary disease overlap syndrome. A total 124 asthma patients acute attack (asthma group), chronic exacerbation (chronic group) and syndrome (asthma-chronic hospitalized the department geriatric respiratory medicine second our hospital from January 2020 to June 2022 were enrolled. Th...

The role of Chlamydia pneumoniae in asthma has drawn much attention in recent years. In this study we assessed the prevalence of C. pneumoniae infections in patients with chronic stable and acute exacerbation of asthma and compared it with normal population. Twenty adult patients with chronic stable asthma and 21 patients with acute exacerbations of asthma and 41 matched control subjects were s...