The present study was conducted with the aim of elucidating the possible role of nitric oxide (NO) in the neuroprotective effects of trazodone used to treat chronic fatigue syndrome (CFS) in mice. Male albino mice were forced to swim for a six minute session each day for 7 days and the immobility period was recorded every other day. Trazodone (5 mg/kg and 10 mg/kg) was administered each day 30 ...

Objective: The in-vivo study was carried out to explore the possible protective effect of thymoquinone on chlorpromazine induced catalepsy and locomotor activity in rats. Materials and Methods: Twenty four rats were used for this study and were divided into four groups, each group containing six animals. The animals were evaluated after repeated administration of chlorpromazine (CPZ) 30 minutes...

The present study was to investigate the toxic impacts of aluminium chloride in locomotion and motor coordination in Wistar rats and to evaluate the protective effects of hydro alcoholic extract of fruit pulp of Hippophae salicifolia D. Don. (HAHS). Wistar Albino rats were assigned into four groups (n=6) and were administered respectively the vehicle, aluminium chloride 300 mg/kg (Aluminium chl...

Mikania scandens (L.) Willd. (Asteraceae), known as climbing hemp weed in English is a herbaceous climbing vine grown as a weed throughout the plains of the Indian subcontinent. The present study evaluated some neuropharmacological activities of hydroalcoholic extract of root from M. scandens (RMS) in experimental animal models. RMS (at 200 and 400 mg/kg body weight, i.p.) was evaluated for ant...

Manahshila (Realgar) is one of the three major Arsenicals used in Ayurvedic therapeutics since ages. It is indicated in skin, respiratory, ophthalmic and psychological disorders. It is mentioned to be the best among Rasayanas and a good aphrodisiac. As Manahshila is indicated in Unmada (Psychological disorder); wide use of Manahshila in the formulations mentioned for psychological disorders; so...

Huntington's Disease (HD) is a common neurodegenerative disorder characterized by motor disturbances, subcortical dementia and psychiatric disturbances. Pathogenesis of HD revolves so far around excitatory amino acids as the primary cause of neuronal loss. However, number of recent reports suggests the involvement of excitotoxicity and oxidative damage. In the present study, first the dose of q...

Many of the drugs leave the market due to their adverse effects than their therapeutic effects. If the pharmacology of the drug and its adverse effect is Circadian Time (CT) dependent, it can be modulated by altering the time of administration of drugs. Chronopharmacology describes the effect of drugs in terms of time of administration. Its main objective is chronotherapy (time based treatment)...

The present study was undertaken to evaluate the possible protective effect of thymoquinone on chlorpromazine induced catalepsy, locomotor activity and cerebral oxidative stress in rats. The rats were divided into four groups, each group containing eight animals. The animals were evaluated after repeated administration of chlorpromazine (CPZ) 30 min before the administration of thymoquinone (TQ...

OBJECTIVES Aluminium, a neurotoxic agent in humans, has been implicated in the pathogenesis of neurodegenerative disorders. In this study, we examined the behavioral and biochemical effects of aluminium in rats with special emphasis on memory centres, namely, hippocampus and frontal cortex. Further, the effect of simvastatin treatment on aluminium intoxication was evaluated. METHODS Rats were...

The plants of the genus Vernonia (Asteraceae) are widely distributed in most tropical and subtropical countries, and have long been used in traditional medicine to treat various types of diseases. In recent years, the interest in the plant-based medicine has increased noticeably worldwide. In the present study we evaluated the anticataleptic efficacy of ethanol extract of Vernonia cinerea L. in...