OBJECTIVE To evaluate by echo- and electrocardiography the cardiac effects of sedation with detomidine hydrochloride, romifidine hydrochloride or acepromazine maleate in horses. STUDY DESIGN An experimental study using a cross-over design without randomization. ANIMALS Eight clinically normal Standardbred trotters. MATERIALS AND METHODS Echocardiographic examinations (two-dimensional, gui...

Forty-three uncooperative children ranging in age from 4-12 yr were pretreated with diazepam, acepromazine or a placebo, depending on their anxiety situations. The results showed that diazepam has a significantly more powerful effect on the successful termination of the dental procedure and on encouraging the cooperation and compliance of patients than acepromazine or placebo. The placebo was a...

seventy seven adult large mixed breed dogs of either sex were included in this study. the animals were randomly divided into four groups and received the following drug combinations intramuscularly: group 1 xylazine (0.5 mg/kg) and acepromazine (0.05 mg/kg), group 2 xylazine (0.8 mg/kg) and acepromazine (0.03 mg/kg), group 3 xylazine (0.3 mg/kg) and acepromazine (0.08 mg/kg) and group 4 xylazin...

Cognitive impairments frequently accompany epileptic disorders. Here, we examine two neuroprotective agents, the noncompetitive NMDA antagonist ketamine and the dopaminergic antagonist acepromazine, for their efficacy in attenuating cognitive impairments in the lithium-pilocarpine (LI-PILO) model of rat limbic epilepsy. Declarative-like cognitive behaviors were assessed in a Morris water maze t...

BACKGROUND In this methodology article a thermal threshold testing device designed to test nociception in cats was assessed in six dogs. The purpose of this study was to investigate baseline reproducibility of thermal thresholds obtained by the contact heat testing device, to assess the influence of acepromazine and levomethadone and fenpipramide in dogs. The relationship between change in noci...

We opportunistically evaluated a combination of acepromazine maleate and medetomidine HCl for use in sedating Rocky Mountain elk (Cervus elaphus nelsoni) and black bears (Ursus americanus) as an alternative to scheduled drug combinations. This combination was safe and effective with limitations inherent in its sedative rather than anesthetic properties.

This study was performing to evaluate the efficiency of Acepromazine, as tranquilizer and efficiency of using mixture of midazolam combination with ketamine as a general anesthetic protocols in rabbits. Ten adult local breed rabbits from both sexes were use in this study. Animals were anesthetized by intramuscularly injection of acepromazine 0.1 mg/kg B.W. five minutes later, animals were givin...

CO(2) administration is a common euthanasia method for research mice, yet questions remain regarding whether CO(2) euthanasia is associated with pain and stress. Here we assessed whether premedication with acepromazine, midazolam, or anesthetic induction with isoflurane altered behavioral and physiologic parameters that may reflect pain or stress during CO(2) euthanasia. Mice were assigned to ...

The effect of tranquilization and anesthesia on high-resolution electrocardiography (HRECG) indices of dogs in the undetermined chronic phase of Chagas’ disease was studied. Eight adult female mongrel dogs were submitted to six protocols: group 1: animals not submitted to tranquilization or anesthesia; group 2: tranquilization with acepromazine; group 3: tranquilization with a combination of ac...