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Viral replication relies on the host to supply nucleosides. Host enzymes involved in nucleoside biosynthesis are potential targets for antiviral development. Ribavirin (a known antiviral drug) is such an inhibitor that suppresses guanine biosynthesis; depletion of the intracellular GTP pool was shown to be the major mechanism to inhibit flavivirus. Along similar lines, inhibitors of the pyrimid...
Campylobacter jejuni, a leading cause of gastroenteritis in humans, is a foodborne pathogen that can reside in chickens, pigs, and cattle. Because resistance to fluoroquinolones and macrolides, which are commonly used to treat human infections, has emerged in C. jejuni, it is imperative to continously monitor resistance patterns and examine the genetic variation in strains from human infections...
W e augmentthe standard Crawford-Sobel(Econometrica 1 982) modelofcheap talkcommunication byallowingthe informed party tousebothcostlessandcostlymessages.Theissuesonwhichwefocus aretheconsequences forcheap talksignalingoftheoption tousea costlysignal(\ burnedmoney");thecircumstances underwhichboth cheap talkandburnedmoneyareusedtosignalinformation;andthe extenttowhichburningmoneyis thepreferred...
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