radionuclide is associated with transferrin, apart from a weak binding to 0-lipoprotein. The thermodynamic con stant for gallium was estimated and indicated that gallium citrate in the presence of serum proteins occurred in a colloid form bound to transferrin. Ultracentrifugation of tumor homogenates obtained from patients who had received i.v. injections of 67Ga citrate for scintigraphy demons...

This study reports the labeling of Gallium-Bleomycin (67Ga-BLM) complex as a radiopharmaceutical and optimization of its labeling conditions; pH, reaction time, temperature, concentration of bleomycin and its biodistribution in normal Bulb C mice. The biodistribution of the complex was compared with 67Ga-Cl3 in 11 selected organs including blood, liver, lung, spleen, muscle, skin, heart, kidney...

The production of 67Ga at iThemba LABS is performed by the proton bombardment of a tandem natZn/natZn target. 67Ga is separated from the target material using a method based on target dissolution, in acidic media, and dual chromatographic methods on Amberchrom CG-161M. The result is a product with a high radionuclidic purity 67Ga having such a low Fe content in the final product that it may be ...

BACKGROUND The GRPR-antagonist-based radioligands [67/68Ga/111In/177Lu]NeoBOMB1 have shown excellent theragnostic profiles in preclinical prostate cancer models, while [68Ga]NeoBOMB1 effectively visualized prostate cancer lesions in patients. We were further interested to explore the theragnostic potential of NeoBOMB1 in GRPR-positive mammary carcinoma, by first studying [67Ga]NeoBOMB1 in breas...

Gallium-67 (67Ga) has been used as a tumor or inflammation-imaging agent in nuclear medicine. We recently reported that the peak of serum alanine aminotransferase (ALT) level was 1 d after carbon tetrachloride (CCl4) treatment in rats. However, the peak of 67Ga uptake by the liver tissue and hepatocytes was 2 d after the treatment. If 67Ga is taken in the hepatic disorder phase, the pattern of ...

BACKGROUND Surgical resection is costly and an unfavorable prognostic factor for primary central nervous system (CNS) lymphoma and germinoma patients. OBJECTIVE To assess the diagnostic and economic impact of combined 201Tl and 67Ga brain SPECT on the management of patients suspected of having CNS lymphoma or germinoma. METHODS Sequential 201Tl and 67Ga brain SPECT was performed in 40 patie...

The results of scintiphotography with gallium-67 (67Ga), renography with technetium-99m diethylene triamine penta-acetic acid, immunofluorescence of antibody coated bacteria, and determination of renal beta 2 microglobulin excretion were compared in 19 patients with upper and 15 patients with lower urinary tract infection. All patients with acute pyelonephritis showed an appreciable unilateral ...

OBJECTIVE Although the use of 18F-fluorodeoxyglucose (FDG) PET for evaluating lymphoma is gaining in popularity, PET is not yet universally available and large prospective comparisons between 67Ga and 18F-FDG PET scans in predicting the long-term outcome after treatment are lacking. Scintigraphic imaging with 67Ga remains an important tool in evaluating the response of lymphoma to therapy. Ther...

There is some disagreement in the literature about the tumour affinity and tumour specificity of gallium-67 (6VGa). The present investigation showed good uptake of 67Ga in most cases of bronchial carcinoma, but some uptake of 67Ga was also found in 30% of those with non-malignant lung lesions. There was no relationship between the uptake of 17Ga and the histo-logical type of bronchial carcinoma...

The uptake of 67Ga citrate has been studied in the regenerating rat liver over a period up to 72 hr after partial hepatectomy. The concentration of 67Ga was found to be maximal (four times that of controls) 42 hr after hepatectomy. This was shown to be related to lysosomal enzyme activity rather than to specific phases of the cell cycle, there being a highly significant correlation (p smaller t...