Using a panel of six human ovarian carcinoma cell lines varying by two orders of magnitude in terms of cisplatin cytotoxicity, we have investigated the in vitro antitumor activity of a series of novel alkylamine ammine dicarboxylatodichloroplatinum(IV) complexes of the general formula c,t,c-[PtCl2(OCOR1)2NH3(RNH2)]. A clear relationship existed between increasing the number of carbons in the R1...

Gastrin releasing peptide (GRP), the human homologue of bombesin (BN), is an autocrine growth factor for small cell lung cancer (SCLC) cells. The synthetic octapeptides [D-cpa1-beta-Leu8-des-Met9]litorin (BIM 26182) and [D-Phe6-Leu13-CH2NH-Cpa14]bombesin(6-14)NH2 (BIM 26189) are potent GRP/BN antagonists of the proliferation of 3T3 and rat pancreas cells. The effect of these analogues on the pr...

Deep long-period events (DLP events) or deep low-frequency earthquakes (deep LFEs) are deep earthquakes that radiate low-frequency seismic waves. While tectonic deep LFEs on plate boundaries are thought to be slip events, there have only been a limited number of studies on the physical mechanism of volcanic DLP events around the Moho (crust-mantle boundary) beneath volcanoes. One reasonable mec...

To enhance developer productivity, all modern integrated development environments (IDEs) include code suggestion functionality that proposes likely next tokens at the cursor. While current IDEs work well for statically-typed languages, their reliance on type annotations means that they do not provide the same level of support for dynamic programming languages as for statically-typed languages. ...

Introduction: The aim of the present study was to analyze influence different music genres, three modulated noises and a pink noise on heart rate (HR) compare between young healthy adults (YA), elderly (EA) patients with Parkinson’s disease (PD). Furthermore, sound condition comparison for each group conducted. Methods: A total 77 subjects (41m/36w) were divided into aged 20–35 years (YA) 55–76...

Endo-beta-1,4-xylanases of the family 11 glycosyl-hydrolases are catalytically active over a wide range of pH. Xyl1 from Streptomyces sp. S38 belongs to this family, and its optimum pH for enzymatic activity is 6. Xyn11 from Bacillus agaradhaerens and XylJ from Bacillus sp. 41M-1 share 85% sequence identity and have been described as highly alkalophilic enzymes. In an attempt to better understa...

First return stroke current waveforms measured by Berger [Methods and results of lightning records at Monte San Salvatore from 1963–1971 (in German), Bull. Schweiz. Elektrotech. ver. 63 (1972) 21403—21422] and Berger and Vogelsanger [Measurement and results of lightning records at Monte San Salvatore from 1955–1963 (in German), Bull. Schweiz. Elektrotech. ver. 56 (1965) 2–22] are used to estima...

The objective of this study is to develop a methodology to integrate multi-source remote sensing data into a homogeneous time series of land cover maps in order to carry out change detection. We developed a method to increase the comparability between land cover maps coming from panchromatic aerial photographs and SPOT XS (multi-spectral ) data by equalizing their levels of thematic content and...

To what extent can changes in PageRank’s damping factor affect node ranking? We prove that, at least on some graphs, the top k nodes assume all possible k! orderings as the damping factor varies, even if it varies within an arbitrarily small interval (e.g. [0.84999 , 0.85001]). Thus, the rank of a node for a given (finite set of discrete) damping factor(s) provides very little information about...