Seed number per pod is an important component of yield traits in soybean (Glycine max L.). In 2010, we identified a natural mutant with an increased number of four-seed pods from a soybean variety named 'Jinong 18' (JN18). Subsequent observations indicated that the trait was stably inherited. To identify and understand the function of genes associated with this mutant trait, we analyzed the gen...

Permanent implantation of radioactive seeds is a viable and effective therapeutic option widely used today for early stage prostate cancer. In order to perform intraoperative dosimetry the seed locations must be determined accurately with high efficiency. However, the task of seed segmentation is often hampered by the wide range of signal-to-noise ratios represented in the x-ray images due to h...

The aim of the present study was to predict pathogenic genes for primary myelofibrosis (PMF) using a system‑network approach by combining protein‑protein interaction (PPI) network and gene expression data with known pathogenic genes. PMF gene expression profiles, known pathogenic genes and protein‑protein interactions were obtained. Using these data, differentially expressed genes (DEGs) were i...

Rapid infall of gas in the nuclei of galaxies could lead to the formation of black holes by direct collapse, without first forming stars. Black holes formed in this way would have initial masses of a few M⊙, but would be embedded in massive envelopes that would allow them to grow at a highly super-Eddington rate. Thus, seed black holes as large as 103 − 10M⊙ could form very rapidly. I will sket...

Secondary malignancy arising following brachytherapy for prostate cancer is rare in medical literature. We present a case of post-brachytherapy soft tissue sarcoma in the pelvis approximately 7 years after 103-P permanent seed implant. The patient developed a large left pelvic mass associated with significant left leg pain. He was not a good candidate for radical surgery, chemotherapy, or re-ir...

Urethral NTCP has been determined for three prostates implanted with seeds based on (125)I (145 Gy), (103)Pd (125 Gy), (131)Cs (115 Gy), (103)Pd-(125)I (145 Gy), or (103)Pd-(131)Cs (115 Gy or 130 Gy). First, DU(20), meaning that 20% of the urhral volume receive a dose of at least DU(20), is converted into an I-125 LDR equivalent DU(20) in order to use the urethral NTCP model. Second, the propag...

Major histocompatibility complex (MHC) class I molecules present thousands of peptides to allow CD8+ T cells to detect abnormal intracellular proteins. The antigen-processing pathway for generating peptides begins in the cytoplasm, and the MHC molecules are loaded in the endoplasmic reticulum. However, the nature of peptide pool in the endoplasmic reticulum and the proteolytic events that occur...