Previous studies have suggested that oxytocin (OT) may be anxiolytic in female laboratory rats and mice. The elevated plus-maze was used to compare anxiety-related behaviors of OT-deficient (OT-/-) and wild-type (OT+/+) mice. Female OT-/- mice displayed increased anxiety-related behavior compared with OT+/+ mice. The percentage of entries (P < 0.0002) and time spent (P < 0.003) in the open arms...

Oxytocin (OT) plays a determining role in social and pair bonding in many vertebrates and increasing evidence suggests it is a social hormone also in humans. Indeed, intranasal administration of OT modulates several social cognitive processes in humans. Electrophysiological studies in humans associated the suppression of EEG in the mu/alpha and beta bands with perception of biological motion an...

The neuropeptide oxytocin (OT) has been shown to influence social cognition, including better recognition of emotion in faces. One potential way which OT improves is by increasing the correspondence between a perceiver's own facial activity and observed expressions. Here we investigate whether increased synchrony while viewing expressions increases recognition, this effect moderated OT. Change ...

Background: The capability of embryonic carcinoma cells P19 in differentiation to Cardiomyocyte was examined through inducing effects of Oxytocin (OT) and 5-Azacytidin (5Az) individually and compared with each other in laboratory condition. Materials and Methods: P19 Embryoid Bodies (EBs) was formed through hanging drops method. Then, EBs were treated with (5Az) or (OT) and the EB medium (Ct...

Gaze following is a basic building block of social behavior that has been observed in multiple species, including primates. The absence of gaze following is associated with abnormal development of social cognition, such as in autism spectrum disorders (ASD). Some social deficits in ASD, including the failure to look at eyes and the inability to recognize facial expressions, are ameliorated by i...

Individuals who suffer from schizophrenia often show a marked deficit in recognition of emotional facial expressions, as part of broader impairment of social cognition. Research has shown that recognition of negative emotions, specifically fear recognition, is particularly impaired among patients with schizophrenia. Recently we reported that intranasal administration of OT (IN OT) increased the...

In a reverse microemulsion consisting of water, oil (octane), an anionic surfactant [aerosol OT (AOT)], and the reactants of the oscillating Belousov-Zhabotinsky (BZ) reaction, a variety of complex spatiotemporal patterns appear. These include traveling and standing waves, spirals that move either toward or away from their centers, spatiotemporal chaos, Turing patterns, segmented waves, and loc...

1 Parr, L. A., Modi, M., Siebert, E., & Young, L. J. (2013). Intranasal oxytocin selectively attenuates rhesus monkeys' attention to negative facial expressions. Psychoneuroendocrinology, 38, 1748-1756. Notes: Intranasal oxytocin (IN-OT) modulates social perception and cognition in humans and could be an effective pharmacotherapy for treating social impairments associated with neuropsychiatric ...

This year is the 50th anniversary of Occupational Therapy (OT) in Iran. This is a hallmark to reflect on our achievements and plan for the future. Iranian OT was established in 1971 in Shafa Rehabilitation Hospital [1]. I can imagine how many people who were the managers facilitating the foundation of the department or those who were overseas occupational therapists were excited at the time. Th...