Although platelet-derived growth factor (PDGF)-BB is thought to participate in vascular disorders, the mechanism of PDGF-induced vascular smooth muscle cell (SMC) proliferation is not fully understood. This study was undertaken to examine the role of c-Jun in PDGF-BB-induced proliferation of rat aortic SMCs. PDGF-BB (10 ng/mL) significantly increased activator protein (AP)-1 DNA binding activit...

Jee Yeon Baek, Kyong Ihn, Hong Koh, Keum Hwa Lee, Min Young Kim, Sinyoung Ji-Man Kang, Jun Yong Choi, Younhee Park, Myoung Soo Kim. Korean J Transplant 2022;36:10. https://doi.org/10.4285/ATW2022.F-0851

Received: 10 Jun 2013 Accepted: 26 Oct 2013

We studied the effect of c-jun depletion in Friend murine erythroleukemia (F-MEL) cells stably transfected with a plasmid that allowed for the glucocorticoid-mediated conditional expression of c-jun antisense sequences. The c-jun cDNA used for the construction of the vector was modified so as to prevent the nonspecific targeting of junB and junD transcripts. High level and rapid induction of c-...

An evaluation of a recent study by Niemann CU, Feiner J, Swain S et al. Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function. New England Journal of Medicine 2015; 373 (5):405-414. PubMed PMID: 26222557. ClinicalTrials.gov number, NCT01680744 Ali Al-Khafaji ( ) Corresponding author: [email protected] Kadir S and Al-Khafaji A. How to cite this article: Targeted temperatu...

Jang Keun Son, Ho Jun Sung, Hye Won Lee, Yeon Jae Jo, Ji Eun Kwak, Tae Su Kang, Junsoo and Heon Sang Jeong. Journal of the Korean Society Food Science Nutrition 2022;51:805-10. https://doi.org/10.3746/jkfn.2022.51.8.805

AP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA). We studied the effects of TPA on the regulation of c-jun gene expression in HL-60 cells during monocytic differentiation. Low levels of c-jun transcripts were detec...

Jun homodimers and Fos/Jun heterodimers bind to the gene for phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK) at three sites within the first 350 base pairs of the promoter. These include CRE-1 (-82 to -90), and P3(II) and P4 (-252 to -258 and -268 to -285, respectively). Over-expression of Jun in HepG2 cells resulted in a 10-15-fold increase in the level of transcription of a chim...