Voltage-sensitive phosphatases (VSPs) are proteins that directly couple changes in membrane electrical potential to inositol lipid phosphatase activity. VSPs thus couple two signaling pathways that are critical for cellular functioning. Although a number of nonmammalian VSPs have been characterized biophysically, mammalian VSPs are less well understood at both the physiological and biophysical ...

The Ellis-van Creveld (EVC) gene is associated with various congenital heart diseases. However, studies on EVC gene variations in ventricular septal defect (VSD) and the underlying molecular mechanisms are sparse. The present study detected 11 single‑nucleotide polymorphisms (SNPs) in 65 patients with VSD and 210 control patients from the Chinese Han population. Of the identified SNPs only the ...

OBJECTIVES We propose a new strategy using coarctation repair together with a polidioxanone absorbable pulmonary artery banding to limit operative risk and to spare infants with aortic coarctation subsequent operations. BACKGROUND The alternative for the surgical management of aortic coarctation associated with ventricular septal defect (VSD) is single-stage repair versus coarctation repair w...

Quantum calculations on the voltage sensing domain (VSD) of the Kv1.2 potassium channel (pdb: 3Lut)have been carried out on a 904 atoms subset of the VSD, plus 24 water molecules. Side chains pointing away from the center of the VSD were truncated; S1,S2,S3 end atoms were were fixed (all calculations); S4 end atoms could be fixed or free. Open conformations (membrane potentials>= 0) closely mat...

The aim of this study was to investigate the clinical efficacy of free dermatoplasty combined with vacuum sealing drainage (VSD) for the treatment of large-area soft tissue defects accompanied by bone exposure in the lower leg (crus). Free dermatoplasty combined with VSD was used to treat 36 patients with large-area soft tissue defects accompanied by bone exposure in the lower leg. The areas of...

A 67-year-old man presented at another hospital with an anterior-wall myocardial infarction. He was transferred to our institution after he went into progressive cardiogenic shock and developed a post-myocardial infarction apical ventricular septal defect (VSD). During high-dose inotropic support, his blood pressure was 78/34 mmHg. Cardiac catheterization revealed a pulmonary artery pressure of...

The voltage sensor domain (VSD) of voltage-gated cation (e.g., Na(+), K(+)) channels central to neurological signal transmission can function as a distinct module. When linked to an otherwise voltage-insensitive, ion-selective membrane pore, the VSD imparts voltage sensitivity to the channel. Proteins homologous with the VSD have recently been found to function themselves as voltage-gated proto...

Background This study aimed to investigate diverse structure of pulmonary blood vessels in patients with combined pulmonary atresia and ventricular septal defect and examine the effect on surgery result. Materials and Methods This cohort retrospective study was conducted on admitta...

Background: Ventricular septal defect (VSD) is the most common congenital heart disease. Transcatheter VSD closure an effective treatment for patients with muscular and perimembranous VSD. However, there a limit data outlet VSD, especially impact to aortic valve leaflet after transcatheter closure. This study aims assess outcomes of outlet-type ventricular (OVSD) 1 postoperative year. <b...

Defect in the ventricular septum with obstruction to right ventricular outflow tract encompass a wide anatomic, physiological and clinical spectrum. Large ventricular septal defects occur with pulmonary stenosis that varies from mild to severe to complete (pulmonary atresia). Very large VSD (size 6.4 cm, in our case) with severe PS is a rare CHD and without surgical correction only 10% patient ...