Aging is associated with decline in a multitude of cognitive processes and brain functions. However, a growing body of literature suggests that agerelated decline in cognition can sometimes be reduced through experience, cognitive training, and other interventions such as fitness training. Research on cognitive training and expertise has suggested that age-related cognitive sparing is often qui...

PURPOSE/OBJECTIVES To test a multicomponent intervention to prevent and treat osteoporosis in breast cancer survivors. DESIGN Descriptive, correlational. SETTING Midwestern urban and rural sites. SAMPLE 27 postmenopausal breast cancer survivors between the ages of 42-65 who had completed treatment, except for tamoxifen, and were not candidates for hormone replacement therapy. METHODS Bo...

While workplace physical exercise can help manage musculoskeletal disorders, less is known about psychosocial effects of such interventions. This aim of this study was to investigate the effect of workplace physical exercise on psychosocial factors among workers with chronic musculoskeletal pain. The trial design was a 2-armed parallel-group randomized controlled trial with allocation concealme...

BACKGROUND While historical declines in human mortality are clearly shaped by lifestyle and environmental improvements, modeling patterns is difficult because intrinsic and extrinsic processes shape mortality through complex stochastic interactions. OBJECTIVE To develop a stochastic model describing intrinsic and extrinsic mortality rates and quantify historical mortality trends in terms of par...

While workplace physical exercise can help manage musculoskeletal disorders, less is known about psychosocial effects of such interventions. This aim of this study was to investigate the effect of workplace physical exercise on psychosocial factors among workers with chronic musculoskeletal pain.The trial design was a 2-armed parallel-group randomized controlled trial with allocation concealmen...

Objective. It has been hypothesized (1) that pain and low vitality lead to an increase in avoidance of activities in persons with early symptomatic knee osteoarthritis (OA), and (2) that avoidance of activities leads to an increase in activity limitations. The present study aimed to evaluate these hypotheses. Methods. Baseline, 2-year and 5-year follow-up data of 828 participants from the Cohor...

BACKGROUND Quality of life (QoL) in patients with chronic disease is impaired and cannot be solely explained by disease severity. We explored whether genetic variability and activity contributes to QoL in patients with Marfan syndrome (MFS), a genetic connective tissue disorder. METHODOLOGY/PRINCIPAL FINDINGS In 121 MFS patients, patient characteristics (i.e. demographics and MFS-related symp...

BACKGROUND The aim of this study was to assess the relationship between health-related quality of life (HRQoL) and the presence or absence of hypertension and diabetes-related chronic complications in type 2 diabetes, and also the association between HRQoL and the number of chronic complications. METHODS One hundred patients with type 2 diabetes were interviewed. HRQoL was evaluated using the...

BACKGROUND Caffeine increases the CAMP production that stimulates spermatozoa movement. Caffeine is also used for induction of in vitro acrosome reaction in mammalian spermatozoa, an important step in achieving fertilization. OBJECTIVE The aim of this study was to assess the effect of caffeine on sperm's motility, vitality and laboratory fertilization rates in mouse in two T6 and M16 media. ...

In the conceptualization of thriving at work, it is emphasized that employees' learning and vitality are two equally important components of thriving and that thriving is facilitated by contextual features and available resources. In this study, we examined the effects of two challenge stressors (time pressure and learning demands) on thriving at work. Based on the literature on challenge and h...