OBJECTIVE To compare ''vaginal hysterectomy alone'' with ''vaginal hysterectomy with prophylactic unilateral sacrospinous ligament fixation'' in terms of intraoperative complications and 1-year anatomic outcomes and symptoms in patients aged over 50 years who presented with stage 3 or 4 pelvic organ prolapse (POP). MATERIALS AND METHODS Thirty-five patients underwent vaginal hysterectomy alon...

OBJECTIVES AND AIM The objective of this study was to determine the origin of an arched back in cows during vaginal examination. Moreover, we tested whether the duration of an arched back and avoidance reactions during vaginal examination can be decreased by epidural anaesthesia or analgesic treatment. MATERIAL AND METHODS Behaviour during cleaning of the perivaginal region and during vaginal...

BACKGROUND Vulvovaginal atrophy (VVA) is characterized by vaginal/vulvar dryness, irritation, dyspareunia, or dysuria. The objective of this study was to examine the efficacy and safety of a very low-dose estradiol vaginal cream (0.003%) applied twice per week in postmenopausal women with VVA-related vaginal dryness. MATERIALS AND METHODS In this phase 3, randomized, double-blind, placebo-con...

Matrix metalloprotease (MMP) activity is increased in the postpartum vagina of wild-type (WT) animals. This degradative activity is also accompanied by a burst in elastic fiber synthesis and assembly. The mechanisms that precipitate these changes are unclear. The goals of this study were to determine how vaginal distention (such as in parturition) affects elastic fiber homeostasis in the vagina...

Suppositories which are designed to melt at the physiological temperature compare to oral administration the rectal or vaginal drug delivery has gain importance therapeutically by avoiding the first pass metabolism. Suppositories are semisolid dosage form; they induce local effect after insertion into the body cavities. Suppositories offers many advantages a) the portal circulation is bypassed ...

Human natural (KTAb), murine monoclonal (KTMAb), and single-chain recombinant (KTScFv) candidacidal antibodies representing the internal image of a killer toxin from the yeast Pichia anomala (KT), characterized by a wide spectrum of antibiotic activity, exerted a lethal effect against a KT-sensitive multidrug-resistant isolate of Mycobacterium tuberculosis. KTMAb and KTScFv were produced by the...

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Polyporus umbellatus is a medicinal fungus, has been used in traditional Chinese medicine for thousands years for treatment of edema, scanty urine, vaginal discharge, jaundice and diarrhea. The structure of a soluble polysaccharide (named PUP80S1), purified from the sclerotia of Polyporus umbellatus was elucidated by gas chromatography (GC), GC-mass spectrometry and nuclear magnetic resonance s...

BACKGROUND: The changes in vaginal acidity impact the composition of microbiota, either commensal or pathogenic. After menopause, tract is more susceptible to infection. Current study was conducted analyze effect on microbiota menopausal women.METHODS: A cross-sectional 32 subjects with vulvovaginal atrophy (VVA). Vaginal pH measured using a strip colorimetric examination. detection Candida sp....