Introduction.  Neuromodulation, mediated by invasive electric stimulation, has been shown to be effective when applied to patients with refractory and intractable neuropathic pain. Recent advances in neurostimulation have broadened the therapeutic uses of this therapy, with the placement of extraspinal electrodes for peripheral nerve stimulation. Methods.  Four patients with long-evolving, pers...

N'-(1-alkyl-2,3-dihydro-2-oxo-1H-3-indolyliden)-4-pyridinecarboxylic acid hydrazide derivatives, 3(a-g), were synthesized in a trial to overcome the resistance developed with the therapeutic uses of isoniazid (INH). The lipophilicity of the synthesized derivatives supersedes that of the INH as expressed by Clog p values. The synthesized compounds and INH were tested against bovin, human sensiti...

Emergence of bacterial strains resistant to antimicrobials is a matter of concern both in human and veterinary medicines. Fluoroquinolones are an important class of antibiotics for treatment of human infections due to gram-negative bacteria such as urinary and gastrointestinal tracts infections [8; 11]. Risk factors for selection of fluoroquinolone-resistant strains are known to be prophylactic...

Where art meets neuroscience: a new horizon of art therapy Advances in human brain imaging help us evaluate brain functions from many perspectives. We can define structural brain differences between individuals with various disorders, such as adult schizophrenia (1) and childhood, autistic-spectrum disorders (2). From these studies, we can posit hypotheses regarding structure, and how structure...