The concept of neurocutaneous melanosis was described in 1948 by Van Bogaert [1] as a nonfamilial neuroectodermal dysplasia, but the first report of an individual with stigmata of neurocutaneous melanosis was made by Rokitansky [2] in 1861. The criteria to be met for diagnosis are large multiple pigmented skin nevi (more than 20 em in diameter) with an excess of melanotic cells in the leptomeni...

Iris melanoma is a primary intraocular tumor with a high potential risc for metastasis, characterized by the presence of a single or a multiple hyperpigmentation focal areas, or diffuse hyperpigmentation of the anterior epithelium of the iris. This hyperpigmentation is due to an abnormal growth and proliferation of melanocytes. However, not any hyperpigmentation should be handled as a melanom, ...

In reviewing the work on the generic hybrids between Platypoecilus maculatus and X iphophorus hellerii, one is confronted by evidence which seems to point to a definite correlation between melanotic conditions in the hybrid fishes and their characteristic color pattern. In some cases, normal and pathological hybrids occur together in the same brood, born and reared in the same aquarium. But it ...

Nevus of Ota (oculodermal melanosis) is a dermal melanocytic hamartoma with bluish hyperpigmentation along the first and second branches of the trigeminal nerve. Extracutaneous involvement, especially ocular, has been reported. A 45-year-old male presented with malignant melanoma of the left orbit in association with nevus of Ota. Being locally invasive, a modified exenteration with frontal fla...

and similar software but a long sequence of consecutive tests is required.12 It might therefore be more effective if a less sensitive test was used in the first place. With the appearance of FASTPAC and other simple test programs it seems that computerised field analysis is approaching the performance of machines such as the venerable Friedmann visual field analyser. Is the emperor's new suit b...