Universal acquired melanosis is a rare cause of diffuse hyperpigmentation of skin and mucosa during childhood. There are only few reported case of this scarce syndrome in medical literature. We report the first case of universal acquires melanosis from Iran in a 4-year-old girl whose skin becomes darker after 2-month of age.

Abstract Background Bladder melanosis is rare. It has previously been described only in the fifth decade of life or beyond; it not childhood. Previous descriptions have generally case reports, and so natural history poorly understood. Urinary symptoms present at time cystoscopy frequently attributed to bladder melanosis. A possible suggested aetiology aberrant migration melanocyte during embryo...

Clinical and histopathological features of four cases of multifocal amelanotic malignant melanoma of the conjunctiva in association with 'acquired melanosis sine pigmento' are reported. The absence ofconjunctival pigmentation in this extremely rare combination of lesions prevented early diagnosis and clinical monitoring. As a result orbital exenteration was required in three cases. This multice...

This paper aims to stimulate debate on the terminology, classification, grading and staging of conjunctival melanosis and melanoma. We audited our results with 76 invasive conjunctival melanomas. Staging according to the sixth edition of the Tumour Node Metastasis (TNM) system did not correlate well with tumour extent and outcome. Approximately 50% of invasive melanomas were associated with 'pr...

Cellular blue nevus is an uncommon pigmented tumor in the conjunctiva, where it generally appears as a deep, circumscribed, pigmented conjunctival mass. We report a case of conjunctival blue nevus that clinically resembled primary acquired melanosis and gave rise to conjunctival melanoma. A 41-year-old man developed a diffuse pigmented mass in the inferior fornix of his left eye. Over a 20-year...

Becker melanosis is an acquired melanosis and hypertrichosis usually in a unilateral distribution, first described in 1948 by S. William Becker. It is characterized by peripubertal development, male preponderance, hypertrichosis, occasional development of acneform lesions within the patch, and rare association with accessory scrotum in the genital region. Androgens may play a significant role i...