When tumor cells are killed by targeted therapy, radiotherapy, or chemotherapy, they trigger their primary releasing pro-inflammatory cytokines. Microenvironmental interactions can also promote heterogeneity and development. In this line, several immune within the microenvironment, including macrophages, dendritic cells, regulatory T-cells, CD8+ CD4+ T involved in clearance of apoptotic through...

Abstract Adoptive cell therapy (ACT) of tumor-infiltrating lymphocytes (TILs) can generate long-term durable responses in patients with melanoma and even successfully treat that are refractory to anti-PD-1 checkpoint blockade. IL-2 is often used expand TILs, however the administration this cytokine induce systemic toxicities patients. Synthetic mimetics have been developed, including neoleukin-...

Glioblastoma is a destructive form of brain tumor that kills most patients within two years of diagnosis.Treatments for glioblastoma include the usual options of surgery, radiation therapy and chemotherapy, but there is no effective treatment. The tumors are capable of spreading tendrils out into the brain and it can grow back in a matter of months after being removed. The cancer stem cell...

Novel biodegradable Poly (L-lactic acid) (PLLA) microspheres containing ytterbium were designed for intra-tumoral radiotherapy, especially for radioembolization. 175Yb possess both therapeutic beta and diagnostic gamma radiations. In this work, process to make ready radiomicrospheres 175Yb(acac)3-loaded PLLA for more consideration has been investigated. The radiomicrospheres were prepared with ...

Novel biodegradable Poly (L-lactic acid) (PLLA) microspheres containing ytterbium were designed for intra-tumoral radiotherapy, especially for radioembolization. 175Yb possess both therapeutic beta and diagnostic gamma radiations. In this work, process to make ready radiomicrospheres 175Yb(acac)3-loaded PLLA for more consideration has been investigated. The radiomicrospheres were prepared with ...

Background: Study in design to incorporate accelerated proliferation correction factors into linearquadratic and multiple-component models. Materials and Methods: Accelerated proliferation rate correction factor has been incorporated into the linearquadratic and the multiple component models by applying accelerated exponential cell growth to explain the tumor cell kinetics and estimates proper ...

Stimulator of interferon genes (STING) contributes to anti-tumor immunity by activating antigen-presenting cells and inducing mobilization tumor-specific T cells. A role for tumor-migrating neutrophils in the effect STING-activating therapy has not been defined. We used mouse tumor transplantation models assessing neutrophil migration into triggered intratumoral treatment with STING agonist, 2?...

Background Anti-N-methyl- d-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune neurological disorder that usually occurs as a paraneoplastic syndrome and is particularly associated with ovarian teratoma. Standard therapy for severe cases is not established and the prognosis in patients who do not respond to first-line treatment is poor. Case Report An 11-year-old boy complained ps...

ABSTRACT APS001F is a strain of Bifidobacterium longum genetically engineered to express cytosine deaminase that converts 5-fluorocytosine (5-FC) 5-fluorouracil. In the present study, antitumor effects plus 5-FC (APS001F/5-FC) in combination with anti-PD-1 monoclonal antibody were investigated using CT26 syngeneic mouse model. Both dosing APS001F/5-FC before and after mAb exhibited as well prol...