Background Neuroticism is a major risk factor for affective disorders. This personality trait has been hypothesized to associate with synaptic availability of the serotonin transporter, which critically controls serotonergic tone in the brain. However, earlier studies linking neuroticism and serotonin transporter have failed to produce converging findings. Because sex affects both the serotoner...

BACKGROUND Several lines of evidence implicate abnormal serotonergic function in suicidal behavior and completed suicide, including low serotonin transporter binding in postmortem studies of completed suicide. We have also reported low in vivo serotonin transporter binding in major depressive disorder (MDD) during a major depressive episode using positron emission tomography (PET) with [(11)C]M...

Engineered peptide based biocompatible, siRNA transporter can transfect primary and TNBC cells with efficient long-term gene silencing. Nanocomplex silencing Notch1 exhibits synergistic interaction metformin amplifies anticancer therapy.

stochastic approach to vehicle routing problem: development and theories abstract in this article, a chance constrained (ccp) formulation of the vehicle routing problem (vrp) is proposed. the reality is that once we convert some special form of probabilistic constraint into their equivalent deterministic form then a nonlinear constraint generates. knowing that reliable computer software for lar...

Harlequin ichthyosis is a life threatening rare skin condition characterized by aberrant differentiation of the epidermis leading to severe barrier defect. It caused mutations in ABCA12 lipid transporter involved transport glucosylceramides from lamellar body lamellae. The current therapeutic approach consists topical emollients and oral administration retinoids causing side effects, so there a...

Cancer cells are metabolically reprogrammed to support their high rates of proliferation, continuous growth, survival, invasion, metastasis, and resistance cancer treatments. Among changes in cell bioenergetics, the role glutamine metabolism has been receiving increasing attention. Increased glutaminolysis is associated with increased expression membrane transporters that mediate cellular uptak...

Although there are remarkable differences in drivers’ behavior as well as vehicles characteristics, road capacity estimationmethods in developing countries are same as developed ones. So, the discrepancy between the theoretical andpractical values of capacity is inevitable. Although, capacity estimation methods can be classified based on numerousparameters, in developing count...

OBJECTIVE To analyze glucose transporter 1 expression patterns in malignant tumors of various cell types and evaluate their diagnostic value by immunohistochemistry. INTRODUCTION Glucose is the major source of energy for cells, and glucose transporter 1 is the most common glucose transporter in humans. Glucose transporter 1 is aberrantly expressed in several tumor types. Studies have implicat...

Wild type PC12 pheochromocytoma cells express a Na(+)-dependent norepinephrine transporter that operates in the uptake of catecholamines, including dopamine. This transporter is not expressed in two spontaneously occurring flat cell variants of PC12 or in two other flat cell variants whose phenotype was induced by expression of the Wnt-1 oncogene. However, each of the flat cell variants, includ...

Glucose is an osmotic agent in the peritoneal dialysis fluid (PDF) to absorb water, sodium and other toxins. absorption from PDF blood impairs (PD) efficiency cause glycemic burden. This extra load leads poor control diabetic patients with PD program. Studies have shown sodium-glucose co-transporter (SGLT)-2 expression mesothelial cells. Blockade of SGLT reduced glucose increment increased rete...