ABSTRACT The miniaturization of high throughput screening has been a growing trend in the field of drug discovery. This paper described a fully-automated droplet microarray system capable of performing high-throughput screening for large number of different samples with ultra-low consumption in the picoliter range. The droplet microarray was automated generated by first forming picoliter drople...

We demonstrate a new technique for measuring the absolute frequencies of atomic transitions. The technique uses a ring-cavity resonator whose length is calibrated using a reference laser locked to the D2 line in Rb. The frequency of this line is known to be 384 230 484.468(10) MHz. Using a second laser locked to the D1 line of Rb, we measure the frequencies of various hyperfine transitions in t...

the Octet platform provides analytical methods for measuring antibody and protein concentrations and binding affinities through various stages of drug discovery and development (table 1). Octet systems circumvent many limitations of ELISA and HPLc assays, enabling informed decisions to be made earlier in both drug and process development – particularly when chromatography and other critical sep...

Rat models of focal cerebral ischemia/reperfusion injury were established by occlusion of the middle cerebral artery. Microarray analysis showed that 24 hours after cerebral ischemia, there were nine up-regulated and 27 down-regulated microRNA genes in cortical tissue. Bioinformatic analysis showed that bcl-2 was the target gene of microRNA-384-5p and microRNA-494, and caspase-3 was the target ...

On October 2-nd 2012 NIST announced its selection of the Keccak scheme as the new SHA-3 hash standard. In this paper we present the first published collision finding attacks on reduced-round versions of Keccak-384 and Keccak-512, providing actual collisions for 3-round versions, and describing attacks which are much faster than birthday attacks for 4-round Keccak-384. For Keccak-256, we increas...

Security of precious data is the most critical design parameter of a communication network. Applications like online banking and military information exchange requires more concern over security regardless of other design issues like power and energy consumption. Data alterations in some applications can lead to severe irreparable losses. This paper presents a novel and reliable Hash algorithm ...

The high level of accumulated expertise by ULIS and CEA/LETI on uncooled microbolometers made from amorphous silicon layer enables ULIS to develop 384 x 288 (1⁄4 VGA) IRFPA formats with 25 μm pixel-pitch designed for high end applications. This detector ROIC design relies on the same architecture as the full TV format ROIC one (detector configuration by serial link, user defined amplifier gain,...

A rapid, high-sensitivity, chemiluminescence (CL) enzyme assay for the determination of organophosphate (OP) residues in milk is presented. The assay for quantification of OP residues in milk is based on the inhibition of enzyme butyrylcholinesterase (BuChE). BuChE was stabilized and preloaded in 384 well plates at 30 °C. The assay permits rapid determination of OPs in milk within 12 min includ...

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