Histopathologic determination of tumor regression provides important prognostic information for locally advanced gastroesophageal carcinomas after neoadjuvant treatment. Regression grading systems mostly refer to the amount of therapy-induced fibrosis in relation to residual tumor or the estimated percentage of residual tumor in relation to the former tumor site. Although these methods are gene...

Energy-saving production is one of the issues that must be paid attention to by today’s manufacturing enterprises. Aiming at problem integrated process planning and scheduling (IPPS) in process, considering Time-of-Use (TOU) tiered electricity price, this paper systematically studies energy-saving order reduce power consumption processing production. To establish multiobjective optimization mat...

Demand for high quality Basmati rice has increased significantly in the last decade. This commodity is highly vulnerable to fraud, especially post COVID-19 era. A unique two-tiered analytical system comprised of rapid on-site screening samples using handheld portable Near-infrared NIR and laboratory confirmatory technique a Head space gas chromatography mass spectrometry (HS-GC-MS) strategy unt...

The underlying pathophysiology of supraventricular and ventricular arrhythmias remains a matter of intense investigation. Though evolving, the contemporary explanations do not encompass all aspects of arrhythmogenicity. An improved understanding of arrhythmia substrate is needed to augment therapeutic capabilities. Our observation and literature sources demonstrate relatively high incidence of ...

OBJECTIVE To review enoxaparin treatment dosing, pharmacokinetics, and clinical outcomes data in patients with renal impairment and to examine the current two-tiered dosing regimen approved by the Food and Drug Administration (FDA). DATA SOURCES A literature search of PubMed (1990-2016) was performed using the search terms low-molecular-weight heparin, unfractionated heparin, bleeding, enoxap...

BACKGROUND Peginesatide is a peptide-based erythropoiesis-stimulating agent that was designed and engineered to stimulate specifically the erythropoietin receptor dimer that governs erythropoiesis. The primary objective of this phase 2 dose-finding study was to determine the once-monthly peginesatide dosing strategy that would maintain hemoglobin within ±1.0 g/dL of baseline values after conver...