ISSN © 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. Dear Editor, Sugammadex is a modifi ed gamma cyclodextrin . Cyclodextrins are water soluble cyclic oligosaccharides with a lipophilic core. Sugammadex has quickly found a place in clinical use for selective antagonism of neuromuscular blockade with rocuronium . Sugammadex quickly encapsulates steroidal neuro...

The methanolic leaf extract of Thuja occidentalis was evaluated for possible sedative activities in mice. Sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping time and elevated-plus maze (EPM) tests at 200mg/kg and 400 mg/kg.  The extract decreased the locomotor activity of mice in hole cross, open field and EPM test and showed the remarka...

Introduction Barbiturates are widely used as anesthetics and may suppress brain energy metabolism and inhibit both glucose transport at blood-brain barrier (BBB) and cerebral glucose utilization (CMRglc) (1). However, commercial pentobarbital is normally supplied in alcoholic solutions containing, for example, ethanol and propylene glycol (2), which affect glucose transport and CMRglc in rat co...

Background: Electroconvulsive therapy (ECT) is an effective treatment in major depressive disorder (MDD). Earlier studies suggest that ketamine has antidepressive effects and prolongs seizure duration in favor of therapeutic efficacy of ECT. A great concern with the use of ketamine is its possible adverse hemodynamic effects during ECT. This study was conducted to compare the hemodynamic effect...

In a canine preparation designed to separate myocardial from peripheral cardiovascular effects of the drug. It was found that thiopentone produced minimal depression of the heart. Only in much greater concentrations was significant depression found. It is concluded that the cardiovascular effects of thiopentone i.v. are not a direct effect on the heart.

THIOPENTONE has been described in such varying terms as a " godsend " and " too dangerous a drug for routine use ". Published figures show that in some centres in America it is used in between onequarter to one-half of all anaesthetics. In Britain thiopentone is more popular and it is safe to say that an intravenous thiobarbiturate is used for the induction of anaesthesia in more than three-qua...

Thirty mothers undergoing elective Caesarean section received thiopentone 3.5 mg kg-1 and 30 received etomidate 0.3 mg kg-1 for induction of anaesthesia. Subsequent management of anaesthesia was identical in both groups. Maternal to fetal base excess differences and the degree of biochemical correlation between mother and infant were more favourable following etomidate than following thiopenton...