although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. the development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. interest in the development of fomepizole was spurred in the 1960s. shortly t...

January, 1862. " A sad tale's best for winter," says Mamillius in the " Winter's Tale." The Quarter's Retrospect will, in some sense, prove a gloss upon this line of the poet, for it will consist of a bare record of murder and suicide; and if the sad recitals we are about to note, should induce greater attention on the part of our readers in the winter time, than at any other period of the year...

Text and speech corpora for training a tale telling robot have been designed, recorded and annotated. The aim of these corpora is to study expressive storytelling behaviour, and to help in designing expressive prosodic and co-verbal variations for the artificial storyteller). A set of 89 children tales in French serves as a basis for this work. The tales annotation principles and scheme are des...

Chaucer’s Cook’s Tale demonstrates the characterization of a riotous apprentice, narrative depiction conflict between that apprentice and his master, master’s issuing questionable “papir” “acquitance” (4404 & 4411) to suggest provocatively linked definitions class depictions order transgression specific guild-oriented mercantile culture fourteenth-century London. Considered within context G...

Transcription activator-like effector nuclease (TALEN)-mediated genome modification has been applied successfully to create transgenic animals in various species, such as mouse, pig, and even monkey. However, transgenic cattle with gene knockin have yet to be created using TALENs. Here, we report site-specific knockin of the transcription activator-like effector (TALE) nickase-mediated SP110 nu...

This paper presents a prosodic analysis of a corpus of 12 tales, read by one male speaker. The work is part of a project which aims at providing storytelling capacities to a humanoid robot. One main point is to improve text-to-speech synthesis expressivity according to a semi-automatic analysis of a given tale. Automatic tagging and prosodic stylization were applied to the corpus. The extracted...

Cosmic rays with energies between 10 and 10 eV exhibit a rich range of features. The energy spectrum changes index at at least two points, known as the “second knee” and the “ankle”. There may be a composition change in this energy regime as well, perhaps indicative of a shift in predominance from galactic to extragalactic sources. The Telescope Array Low-Energy Extension — planned for construc...

The ability to conditionally rewire pathways in human cells holds great therapeutic potential. Transcription activator-like effectors (TALEs) are a class of naturally occurring specific DNA binding proteins that can be used to introduce targeted genome modifications or control gene expression. Here we present TALE hybrids engineered to respond to endogenous signals and capable of controlling tr...

A young Prince decides to explore the Father’s Kingdom and aims to reach its furthermost boundaries. He starts from the City with a Caravan and seven fast and strong Messengers. They have the task to maintain the communications between the Caravan and the City during the exploration, going back and forth between the Caravan and the City while the Caravan inexorably goes away. Drawing inspiratio...

Contro il background di un caso clinico in particolare, una situazione di presa di decisione al termine della vita, si formula l’ipotesi che gli approcci medici classici basati sull’etica non rendano giustizia alla complessità di una tale situazione, e non rappresentino uno strumento metodologico e sistematico adeguato per analizzare il conflitto sul piano etico. Conseguentemente, si propone lo...