background: the fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.the high linear energy transfer (let) of alpha radiation to the targeted cancer cellscauses double strand breaks in dna. at the same time, the short range radiation spares adjacent normal tissues. this targeted approach complements conventional external beam radiotherapy and ch...

Hyperthrofic lichen planus is considered a variant of lichen planus with marked epidermal hyperplasia in response to persistent itch. It is clinically, characterized by symmetric hyperkeratotic plaques, of purplish-grey color, often located in the pretibial region. Intense pruritus, refractoriness to conventional treatments and the possibility of association of the long-term injuries with squam...

Hyperthrofic lichen planus is considered a variant of lichen planus with marked epidermal hyperplasia in response to persistent itch. It is clinically, characterized by symmetric hyperkeratotic plaques, of purplish-grey color, often located in the pretibial region. Intense pruritus, refractoriness to conventional treatments and the possibility of association of the long-term injuries with squam...

Given these and the many other agents in the ‘pipeline’, patients in the future will have many options for keeping their disease in control. The refinement of existing therapies is another factor that has led to improvement in outcomes. Both Elsayad et al. [4] and Dabaja et al. [5] in their papers discuss the reconsideration of radiation therapy dose for managing mycosis fungoides. In 1978, at ...

Facilitačně systémová terapie je uceleným terapeutickým systémem, vycházejícím z metodologické báze Lurijovy neuropsychologické školy, opírající se o Lurijovu představu fungování mozku, vychází jeho odkazu i díla mnoha kolegů následovníků. Je zároveň souborem postupů a metod reflektujícím potřeby současné české (a s mírnou jazykovou modifikací) slovenské ...

Melanocytic nevi represent a widespread cutaneous finding. Nevertheless, the presence of mycosis fungoides and melanocytic nevi in the same location is an extremely rare event. We report the case of a patient affected by mycosis fungoides and treated with PUVA therapy, with complete remission of the disease. Eight years after therapy discontinuation, he presented epidermal scaling and an erythe...