نتایج جستجو برای: sy5y cells

تعداد نتایج: 1383827  

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2004
Kathleen Newhouse Shih-Ling Hsuan Sandra H Chang Beibei Cai Yupeng Wang Zhengui Xia

Rotenone is a naturally derived pesticide that has recently been shown to evoke the behavioral and pathological symptoms of Parkinson's disease in animal models. Though rotenone is known to be an inhibitor of the mitochondrial complex I electron transport chain, little is known about downstream pathways leading to its toxicity. We used human dopaminergic SH-SY5Y cells to study mechanisms of rot...

Journal: :Journal of neurochemistry 1996
D M Slowiejko E L McEwen S A Ernst S K Fisher

The possibility that clathrin plays a role in the agonist-mediated sequestration of muscarinic cholinergic receptors in human SH-SY5Y neuroblastoma cells has been investigated by the application of experimental paradigms previously established to perturb clathrin distribution and receptor cycling events. Preincubation of SH-SY5Y cells under hypertonic conditions resulted in a pronounced inhibit...

2013
Gwon-Soo Jung Kyeong-Min Lee Jin-Kyu Park Seong-Kyoon Choi Won Bae Jeon

In this study, we aimed to compare the morphogenetic and neuronal characteristics between monolayer cells and spheroids. For this purpose, we established spheroid formation by growing SH-SY5Y cells on the hydrophobic surfaces of thermally-collapsed elastin-like polypeptide. After 4 days of culture, the relative proliferation of the cells within spheroids was approximately 92% of the values for ...

Journal: :Molecular medicine reports 2014
Yawen Li Shiyuan Xu Qingguo Zhang Le Li Luying Lai Ting Zheng Jiaoling Su Naimei Yang Yuantao Li

The aim of this study was to investigate susceptibility to the neurotoxicity of local anesthetic agents in a model of gestational diabetes mellitus (GDM). SH-SY5Y cells were cultured at different concentrations of glucose and subsequently treated with 1 mmol/l bupivacaine for 6 h. Reactive oxygen species (ROS) production and apoptosis were assessed using flow cytometry in each group of cells. T...

Journal: :Biomicrofluidics 2010
Bao-Xian Shi Yu Wang Tin-Lun Lam Wei-Hua Huang Kai Zhang Yun-Chung Leung Helen L W Chan

A method for monitoring the biological exocytotic phenomena on a microfluidic system was proposed. A microfluidic device coupled with functionalities of fluorescence imaging and amperometric detection has been developed to enable the real-time monitoring of the exocytotic events. Exocytotic release of single SH-SY5Y neuroblastoma cells was studied. By staining the cells located on integrated mi...

Journal: :International journal of translational medicine 2022

Protein aggregation is a common characteristic of several human diseases such as Alzheimer’s disease. Recent evidence has indicated that the peptides p53 also marked in cancer cells. The aim this study was to correlate Thioflavin T (ThT) data with different cellular viability assays (Neutral Red and MTT) SH-SY5Y neuroblastoma cells HT-29 colon treated doxorubicin, classical antineoplastic agent...

2014
Vasantha Kumar Bhaskara Indra Mohanam Meena Gujrati Sanjeeva Mohanam

BACKGROUND Neuroblastoma is the most common extracranial pediatric solid tumor. Intermittent hypoxia, which is characterized by cyclic periods of hypoxia and reoxygenation, has been shown to positively modulate tumor development and thereby induce tumor growth, angiogenic processes, and metastasis. Bone is one of the target organs of metastasis in advanced neuroblastoma Neuroblastoma cells prod...

Journal: :Molecular pharmacology 2013
Simona Magi Sara Arcangeli Pasqualina Castaldo Annamaria Assunta Nasti Liberato Berrino Elena Piegari Renato Bernardini Salvatore Amoroso Vincenzo Lariccia

It is known that glutamate (Glu), the major excitatory amino acid in the central nervous system, can be an essential source for cell energy metabolism. Here we investigated the role of the plasma membrane Na(+)/Ca(2+) exchanger (NCX) and the excitatory amino acid transporters (EAATs) in Glu uptake and recycling mechanisms leading to ATP synthesis. We used different cell lines, such as SH-SY5Y n...

2017
Wenbin Wan Lirong Jin Zigao Wang Lingyan Wang Guoqiang Fei Fanlong Ye Xiaoli Pan Changpeng Wang Chunjiu Zhong

Growing evidence has indicated that iron deposition in the substantia nigra plays an important role in Parkinson's disease (PD). However, the underlying mechanism is still elusive. Using primary dopaminergic neurons and SH-SY5Y cells cultured in vitro, we observed that iron loading increased α-synuclein and reactive oxygen species (ROS) levels in these cells but did not affect the intracellular...

Journal: :International journal of clinical and experimental medicine 2015
Li-Yan Wang Xia Li Yu-Zeng Han

Bupivacaine, an amide type long-acting local anaesthetic is commonly employed for epidural anesthesia and as well for nerve blockades. However, studies have shown neurotoxicity following local administration of bupivacaine raising concerns over the use of the drug. Compounds that could minimize or inhibit toxic effects of bupivacaine are of high value in operative settings and in pain managemen...

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