Model Suppose a set G of genes was sequenced in a collection P of patients, all of whom have the same disease. Each sequenced gene2 g ∈ G partitions the set of patients into two subsets: the P(g), with patients with a mutation in g, and the P̄(g), with patients with no mutation in g. The goal is to identify genes whose mutational status is highly correlated with the survival time, in the sense t...

The relationship between the way in which normal hemopoietic stem cells respond to irradiation alone or in the presence of bleomycin sulfate (BLM-S) and actinomycin 0 (ACT-D) was investigated. Single doses of BLM-S at 0.3 mg/kg and ACT-O at 0.10 mg/kg body weight were injected intravenously 1-6 hours prior to whole body irradiation and treatment was repeated twice more with time intervals....

BACKGROUND Few studies have reported population-based outcomes for aortic valve replacement patients. METHODS Patients with severe aortic valve stenosis who underwent aortic valve replacement with or without concomitant coronary artery bypass graft surgery from January 1, 2003, to December 31, 2005, were included in the study. Statistical models were developed to identify significant risk fac...

OBJECTIVE To compare integrated automated load distributing band CPR (iA-CPR) with high-quality manual CPR (M-CPR) to determine equivalence, superiority, or inferiority in survival to hospital discharge. METHODS Between March 5, 2009 and January 11, 2011 a randomized, unblinded, controlled group sequential trial of adult out-of-hospital cardiac arrests of presumed cardiac origin was conducted...

We compared the survival of medically and surgically treated coronary artery disease patients in subgroups of patients to determine those most or least likely to benefit from surgery after an average of 5.5 years of follow-up. Cox's regression model for survival analysis was used in conjunction with data from all patients to estimate and test for the significance of the effects of surgery on su...

AIMS The correction of anaemia in chronic heart failure (CHF) has been suggested to be associated with an improvement in symptoms and cardiac function. We aimed to investigate the relationship between the concentration of haemoglobin and survival in CHF. METHODS AND RESULTS We analysed haemoglobin concentrations in 3044 patients recruited in the Evaluation of Losartan In The Elderly (ELITE II...

INTRODUCTION AND OBJECTIVES Despite recent improvements in therapy, heart failure is still associated with high mortality and hospitalization rates. New management strategies such as heart failure clinics could help to improve this situation. PATIENTS AND METHOD We analyzed the clinical features, treatment, morbidity and mortality of 3909 patients with heart failure followed at 62 heart failu...

In most habitats, fluctuating environmental conditions create periods of compromised survival for metabolically active organisms. response, various strategies have evolved, including the formation resilient resting cells. We assessed biodiversity lysis-resistant bacteria in three different environments by applying a harsh physicochemical treatment to samples. The bacterial diversity fraction wa...

Conventionally, the time between diagnosis and date of last follow up or death is used to plot survival curves for patients with cancer. This ignores the patient's expected life span had the patient been healthy at the time of diagnosis. In human terms the impact of a projected prognosis of 10 year survival on a woman diagnosed as having breast cancer, for example, may be different depending on...

Current guidelines for the management of heart failure (HF) divide patients with HF into 2 categories: those with reduced ejection fraction (EF of ≤40%; HFrEF) and those with preserved ejection fraction (>40%; HFpEF). It has been recognized that a subset of patients with HFpEF previously had HFrEF. These patients with recovery or improvement in EF (HFiEF) may be clinically distinct from those w...