Bitter melon is a fruit that was famous for its bitter taste and contains chemical compounds are proven to have effects such as antidiabetic, anti-inflammatory, antipyretic, antioxidant. One of the prerequisites plant be developed into drug by testing subchronic toxicity. This study goal determine presence toxic not detected in acute toxicity test. A total 40 wistar rats were divided group cont...

Trazodone is a selective antagonist and serotonin reuptake inhibitor used in medicine to treat anxiety. Toxicological studies of trazodone succinate were carried out on the basis Department Pharmacology Veterinary Faculty Stavropol State Agrarian University, Russia.
 The results obtained study acute toxicity drug Express Uspokoin® tablets allow us identify new as belonging moderately dange...

Chronic inhalation bioassays in rodents are used to assess pulmonary carcinogenicity for purposes of hazard identification and potentially for risk characterization. The influence of high experimental doses on tumor development has been recognized for some time and has led to the concept of maximum tolerated dose (MTD) for dose selection, with the highest dose being at the MTD. Exposure at the ...

Introduction: The impact of aromatic plants used in cooking on health is indisputable.
 This study aims to evaluate the vitro cytotoxicity Artemia salina, acute and 28 days subchronic toxicity X. aethiopica dried fruit like spice Togo by oral administration extract female Wistar rats.
 Results: A. salina assay showed that hydroalcoholic presented any toxicity. LC50 values brine shrimp...

In order to evaluate the clinical safety of a modification of the classical formula Si Jun Zi Tang (Wei Qi Booster®a (WQB)), acute and subchronic mouse oral toxicity tests were conducted. An acute oral 7-day mouse study using 80 Kunming (KM) mice randomly divided into a saline control and 7 dosages of WQB (range 2.0 -15.06 g/kg BW) was conducted to determine LD50. No mortality or adverse effect...

Neurotoxicity of tricresyl phosphates (TCPs) and jet engine oil (JEO) containing TCPs were evaluated in studies conducted in both rat and hen. Results for currently produced samples ("conventional" and "low-toxicity") were compared with published findings on older samples to identify compositional changes and relate those changes to neurotoxic potential. Finally, a human risk assessment for exp...

Polyprenols of Ginkgo biloba L. leaves (GBP) are a new type of lipid with 14-24 isoprenyl units, which in humans have strong bioactivity like the dolichols. A large amount of work showed that GBP had good antibacterial activity and powerful protective effects against acute hepatic injury induced by carbon tetrachloride and alcohol, as well as antitumor activity, but the safety of GBP was not co...