The observer design problem for a class of cell population balance models, describing the time evolution mass density distribution function and substrate concentration in continuous-stirred tank bioreactor with irregular discrete-time measurements is considered. model consists partial integro-differential equation coupled an ordinary differential equation. Using theory impulsive systems suffici...

BACKGROUND In Pichia pastoris bioprocess engineering, classic approaches for clone selection and bioprocess optimization at small/micro scale using the promoter of the alcohol oxidase 1 gene (PAOX1), induced by methanol, present low reproducibility leading to high time and resource consumption. RESULTS An automated microfermentation platform (RoboLector) was successfully tested to overcome th...

The number of bioprocess applications for microalgae has increased in recent years, particularly in the fi eld of biofuel production. The combination of the New Brunswick CelliGen 310 stirred-tank bioreactor and the DASGIP LED Illumination System creates a bioreactor setup which is capable of supporting high density microalgal growth. Using the stand-alone Eppendorf DASGIP PBR4 Module, LED illu...

Limited available water resources have rendered wastewater reuse an important issue to specialists in most developed countries, today. The current study works on membrane filtration for treatment of industrial wastewater. By comparing the two methods of membrane bioreactor (MBR) and hybrid membrane electro bioreactor (MEBR) processes, it finds that earlier fouling in the membrane occurs in the ...

Control of dissolved oxygen tension (DOT) in stirred tank bioreactors (STB) is commonly performed by manipulation gas flow or agitation. However, control systems using this strategy directly alter hydrodynamic conditions thus interrelating and momentum transfer effects the culture. The aim study was to develop evaluate an alternative DOT system algorithm that allows further separately. A novel ...

Optimal oxygen supply is vitally important for the cultivation of aerobically growing cells, as it has a direct influence on cell growth and product formation. A process engineering parameter directly related to volumetric mass transfer coefficient kLa. It influences kLa computing time different interfacial force population balance models in stirred bioreactors that have been evaluated this stu...