نتایج جستجو برای: sk hf
تعداد نتایج: 29086 فیلتر نتایج به سال:
Rationale: Ca 2؉-activated K ؉ channels are present in a wide variety of cells. We have previously reported the presence of small conductance Ca 2؉-activated K ؉ (SK or K Ca) channels in human and mouse cardiac myocytes that contribute functionally toward the shape and duration of cardiac action potentials. Three isoforms of SK channel subunits (SK1, SK2, and SK3) are found to be expressed. Mor...
Introduction & Objective: Obesity is independently associated with increased oxidative stress in men and women. Natural antioxidants showed substantial antioxidative and anti-inflammatory activities in vivo. The aim of this study was to examine the preventive effect of antioxidant supplements and/or restricted diet on the stress oxidative index (8-Iso-PGF2α) and total antioxidant capacity (T...
The permeability and coupled behavior of pore pressure and deformations play an important role in hydraulic fracturing (HF) modeling. In this work, a poroelastic displacement discontinuity method is used to study the permeability effect on the HF development in various formation permeabilities. The numerical method is verified by the existing analytical and experimental data. Then the propagati...
Vitamin D deficiency is common among the elderly with and without heart failure (HF). This study was designed to identify the degree of vitamin D deficiency among HF and Non- HF elderly with cardiovascular disease. In this study, fifty hospitalized elderly patients with HF (26 women and 24 men, age range 60-90 years) and fifty elderly without HF were randomly selected. The level of serum 25-hyd...
The mammalian protease plasminogen can be activated by bacterial activators, the three-domain (alpha, beta, gamma) streptokinases and the one-domain (alpha) staphylokinases. These activators act as plasmin(ogen) cofactors, and the resulting complexes initiate proteolytic activity of host plasminogen which facilitates bacterial colonization of the host organism. We have investigated the kinetic ...
The formation of acquired drug resistance is a major reason for the failure of anti-cancer therapies after initial response. Here, we introduce a novel model of acquired oxaliplatin resistance, a sub-line of the non-MYCN-amplified neuroblastoma cell line SK-N-AS that was adapted to growth in the presence of 4000 ng/mL oxaliplatin (SK-N-ASrOXALI4000). SK-N-ASrOXALI4000 cells displayed enhanced c...
Shikonin (SK), a naturally occurring naphthoquinone, exhibits antitumor activity. However, its precise mechanisms of action are unknown. In the present study, the effects of SK on NCI-H460 human lung cancer cells were investigated. It was found that SK reduced cell viability and induced apoptosis in the NCI-H460 cells. Additionally, SK inhibited extracellular signal-regulated kinase (ERK) activ...
Let X1, X2, . . . , Xn be independent random variables and Sk = Pk i=1 Xi. We show that for any constants ak, P( max 1≤k≤n ||Sk| − ak| > 11t) ≤ 30 max 1≤k≤n P(||Sk| − ak| > t). We also discuss similar inequalities for sums of Hilbert and Banach space valued random vectors.
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