Selective serotonin reuptake inhibitor (SSRI) medications are the most common antidepressant treatment used during pregnancy and the postpartum period. Up to 10% of pregnant women are prescribed SSRIs. Serotonin plays an integral part in neurodevelopment, and questions have been raised about the placental transfer of SSRIs and the effects of preventing reuptake of presynaptic serotonin on fetal...

Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown. Transient inhibition of 5-HTT during early development with fluoxetine, a commonly used serotonin selective reuptake inhibitor, produced abnormal emotional behaviors in adult mice. This effect mimicked the behavioral...

We isolated two mutants defective in the uptake of exogenous serotonin (5-HT) into the neurosecretory motor neurons of Caenorhabditis elegans. These mutants were hypersensitive to exogenous 5-HT and hyper-responsive in the experience-dependent enhanced slowing response to food modulated by 5-HT. The two allelic mutations defined the gene mod-5 (modulation of locomotion defective), which encodes...

Fluoxetine and its successors (Table 1) differ from the heterocyclic antidepressants in that they inhibit serotonin reuptake, with little or no effect on other receptor sites. As a result of this specificity, these agents are referred to as selective serotonin reuptake inhibitors (SSRIs). Their clinical efficacy is believed to be the result of an initial increase in serotonin concentrations (in...

conclusions these results provide empirical support for conducting a further study on comparing different add-on strategies for treating drug-induced sd. background antidepressant-induced sexual dysfunction (sd) is a common problem, associated with a significant risk of non-adherence. selective serotonin reuptake inhibitors (ssris) are associated with a substantial risk of sd. only 10 % of pati...

depression is a serious disorder in today’s society, with the estimates of lifetime prevalence being as high as 21% of the general population in some developed countries. as defined by the american psychiatric association, depression is a heterogeneous disorder often manifested with symptoms at the psychological, behavioral, and physiological levels. such patients are often reluctant to take sy...