Differential degree of tolerance has been reported to develop for anticonvulsant, sedative and skeletal muscle relaxant effects of benzodiazepines (BZDs). Acute treatment with BZDs reportedly reduces the formation of gastric stress ulcers and attenuates stress-induced immunosuppression. The present study investigates whether tolerance develops to these antistress effects of BZDs by using diazep...

BACKGROUND In the recent past, propofol was temporarily removed from the emergency department (ED) for use in procedural sedation. We sought to determine which agents replaced it in clinical practice and the impact this change had on turnaround times (TAT) for sedated patients. METHODS This study is a retrospective chart review at a level one trauma center. Patients receiving sedative agents ...

Introduction: Butorphanol, an opioid derivative has been shown to have, in addition to its analgesic properties, several other advantageous effects like antistressor, sedative and anti-shivering action. The efficacy and safety profile of ketorolac, yet another widely used post-operative analgesic is well documented. This study aims to compare the two analgesics. Aims and objectives: This study ...

The sedative activity of eight aromatic natural medicines that are traditionally used in Japanese scent sachets was examined using an open field test with mice. Galangal (Kaempferia galanga), patchouli (Pogostemon cablin), sandalwood (Santalum album), spikenard (Nardostachys chinensis), cinnamon (Cinnamomum cassia), clove (Syzygium aromaticum), star anise (Illicium verum), and borneol (Dryobala...

Sedation and analgesia are important aspects of patient care on the intensive care unit (ICU), yet relatively little information is available on common sedative and analgesic practice. We sought to assess international differences in the prescription of sedative and analgesic drugs in western European ICUs by means of a short, self-administered questionnaire. Six hundred and forty-seven intensi...

The bioavailability of ciprofloxacin after its administration through a nasogastric (NG) feeding tube was studied in six healthy volunteers. Each subject received, on separate occasions, an intact 750-mg ciprofloxacin tablet, a crushed tablet as a suspension through an NG tube, and a crushed tablet as a suspension through an NG tube while receiving enteral feeding. No statistically significant ...

Clopidogrel bisulphate (anti-coagulant drug) is an enantio-selective chrial drug and needs to be monitored for the active form in tablet formulation. Hence, a stable tablet formulation was developed for clopidogrel using two different disintegrants of LHPC (to match as closely as possible to innovator tablet) and PVPP XL. Tablets were evaluated for stability analysis using validated analytical ...

The purpose of the present work was to prepare buccal adhesive tablets of miconazole nitrate. The simplex centroid experimental design was used to arrive at optimum ratio of carbopol 934P, hydroxypropylmethylcellulose K4M and polyvinylpyrollidone, which will provide desired drug release and mucoadhesion. Swelling index, mucoadhesive strength and in vitro drug release of the prepared tablet was ...

This experiment tested the influence of the lubricant magnesium stearate on the effectiveness of the drug acetaminophen in a mixture of glidants and excipients. There are many factors that can cause variation in the effectiveness of drugs in tablet form. Chief among them are the lubrication and glidant percentages, shear rate, tablet hardness and hydrophobicity. In order to allow the powder to ...

Tablet PCs are a new generation of notebook computers which provide multimodal input options of pen, voice and keyboard. Recently, these portable and flexible Tablet PCs have attracted attention as a potential tool in academic environments. This paper reviews the current use of Tablet PCs in teaching computer science and software engineering courses, presenting lectures and papers, and creating...