BACKGROUND Matrix-metalloproteinases (MMP) and cancer cell invasion are crucial for solid tumour metastasis. Important signalling events triggered by inflammatory cytokines, such as tumour necrosis factor α (TNFα), include Src-kinase-dependent activation of Akt and focal adhesion kinase (FAK) and phosphorylation of caveolin-1. Based on previous studies where we demonstrated amide-type local ana...

Objective: To compare the postoperative analgesic effects of 0.2% ropivacaine with Dexmedetomidine (2 g/kg) and tramadol mg/kg) among pediatric patients undergoing infra umbilical surgery.Material Methods: This hospital based, randomized double blind interventional study included 60 patients, aged 1–7 years, having American Society Anaesthesiology grade I II, weighing 7-25 kg, infraumbilical su...

PURPOSE To determine whether the addition of 0.4% ropivacaine to the standard 2% lidocaine peribulbar anesthetic block improves pain scores during suture adjustment in patients undergoing strabismus surgery with adjustable sutures. METHODS Prospective, double-blind study of 30 adult patients aged 21-84 years scheduled for elective strabismus surgery with adjustable sutures. Patients were divi...

Background: The propyl derivative of the pipecoloxylidides was less toxic than the butyl derivative (bupivacaine). Further work revealed that the nerve blocking properties of the R and S enantiomers were similar but that the S-enantiomer was less cardiotoxic. Thus the S enantiomer of the propyl derivative (Ropivacaine) was chosen for further development.Ropivacaine,structurally resembling bupiv...

BACKGROUND Lipid emulsion treatment appears to have application in the treatment of local anesthetic-induced cardiac arrest. To examine whether the efficacy of lipid resuscitation in the treatment of local anesthetic-induced cardiac arrest is affected by lipophilicity, the effects of lipid infusions were compared between levobupivacaine-induced (high lipophilicity) and ropivacaine-induced (lowe...

BACKGROUND The sympathetic block of upper limb leading to increased blood flow has important clinical implication in microvascular surgery. However, little is known regarding the relationship between concentration of local anesthetic and blood flow of upper limb. The aim of this dose-response study was to determine the ED50 and ED95 of ropivacaine in blood flow after supraclavicular block (SB)....

BACKGROUND AND PURPOSE High-volume infiltration analgesia may be effective in postoperative pain management after hip arthroplasty but methodological problems prevent exact interpretation of previous studies. METHODS In a randomized, double-blind placebo-controlled trial in 12 patients undergoing bilateral total hip arthroplasty (THA) in a fast-track setting, saline or high-volume (170 mL) ro...

A healthy 18-yr-old male (weight 60 kg, height 167 cm), with a history of febrile convulsions in childhood, developed a grand mal convulsion 10 min after the second of two injections of ropivacaine 150 mg, both given incrementally 15 min apart (total 300 mg), for combined axillary/interscalene brachial plexus block. Treatment was with oxygen, lung ventilation, and i.v. midazolam, and the patien...

Popliteal or otherwise called Baker’s cyst represents a fluid distension of the gastrocnemiosemimembranosus bursa and is usually incidentally found on imaging studies. However, the clinical manifestation of symptomatic Baker’s cyst is similar to thrombophlebitis hence the term pseudothrombophlebitis syndrome. We add to the literature a case of a partially ruptured popliteal cyst in which locall...

Background: The regional anaesthesia has lot of benefits compared to general for lower abdominaland limb surgeries. Epidural is an ideal anesthetic technique abdominal and lowerlimb additives are used with Anesthetics Early onset action, To prolong the duration ofaction, Analgesia Improving quality block.Aims Objectives: aim this study was clinical efficacy Dexmedetomidine versus Fentanylas add...