Bluetongue virus (BTV) infection effectively activates the innate immune response, followed by expression of interferon (IFN) and multiple interferon-stimulated genes (ISGs). ISG15 is one most induced ISGs, often plays a role in inhibiting replication. This study aims to explore specific mechanisms ovine (oISG15) BTV infection. We found that transcription level oISG15 was upregulated time-depen...