9 Department of Pharmacology, University of Tennessee College of Medicine 10 Memphis, TN 38163 11 12 13 Corresponding author: Fu-Ming Zhou, Department of Pharmacology, University of Tennessee 14 College of Medicine, Memphis, TN 38163 15 Phone: 901-448-1779, 16 Email: [email protected] 17 18 Abstract 202 words 19 Introduction 507 words 20 Discussion 1519 words 21 Number of pages 36 (including tit...

GEC1-κ OPIOID RECEPTOR BINDING INVOLVES HYDROPHOBIC INTERACTIONS: GEC1 HAS CHAPERONE-LIKE EFFECT Yong Chen, Chongguang Chen, Evangelia Kotsikorou, Diane L. Lynch, Patricia H. Reggio and Lee-Yuan Liu-Chen 1 Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA 2 Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, NC, USA Running t...

To investigate the molecular mechanism of Ziziphi spinosae semen and Schisandrae chinensis fructus in treatment insomnia is objective study. First, compounds corresponding target genes were obtained by traditional Chinese medicine systems pharmacology database analysis platform associated with GeneCards database. The results imported into Cytoscape software to construct a network (Herbal-active...

rhus coriaria l. is known as sumac. r. coriaria extracts are important in drug development with numerous pharmacological reputations in the south-eastern anatolia, mediterranean area and western asia especially in iran. regarding the new multi-functional properties of r. coriaria and the related valuable ongoing reports, we were prompted to review the phytochemical and pharmacological propertie...

Qing’E pills are a classical formula in traditional Chinese medicine that has the effect of tonifying kidneys and strengthening bones, first appearing tonic formulae prescriptions peaceful benevolent dispensary (10th century CE). To preliminarily elucidate potential mechanisms treatment postmenopausal osteoporosis based on network pharmacology. The principal components corresponding protein tar...

In 2008, half of the 15 best-selling cardio-vascular drugs (those with sales of over $2 billion), the sartans, were developed over 30 years ago. A lipid-lowering drug developed over 40 years ago (fenofibrate) also made it into the top fifteen. Rare are those developed more recently. One example is ezetimibe developed in the 1990s. Drugs acting on cholesterol levels such as fenofi-brate, ezetimi...