BACKGROUND The current study investigated the effects of Piper longumine on radio-sensitization of human breast cancer MDA-MB-231 cells and underlying mechanisms. MATERIALS AND METHODS Human breast cancer MDA-MB-231 cells were cultured in vitro and those in logarithmic growth phase were selected for experiments divided into four groups: control, X-ray exposed, Piper longumine, and Piper longu...

Introduction: Becuase of the most radiation dose receiving by human is related to medical radiation exposures, and also Computed Tomography (CT) is a special type of radiography that is one of the main method of radiation exposure today, and it's growing increasingly. Therefore, radio technologists working in CT scan imaging centers, are at risk of radiation. Due to the high am...

Paclitaxel is a chemotherapeutic agent with potent microtubule stabilizing activity that arrests cells in G2-M. Because G2 and M are the most radiosensitive phases of the cell cycle, paclitaxel has potential as a cell cycle-specific radiosensitizer. In this study, we investigated the ability of paclitaxel to increase tumor radioresponse in vivo using a murine mammary carcinoma and the dependenc...

Background: Breast cancer is a common disease in radiation oncology. We evaluated the radiation dose received by breast cancer patients, an often-neglected concern. Materials and Methods: The total effective radiation dose in 101 breast cancer patients was calculated by summing the effective doses of individual diagnostic imaging tests from the first hospital visit to the initiation of radiothe...

Background: The amount of average dose enhancement in tumor loaded with 10B may vary due to various factors in boron neutron capture therapy.Objective: This study aims to evaluate dose enhancement in tumor loaded with 10B under influence of various factors and investigate the dependence of this dose enhancement on neutron spectra changes.Material and Methods: In this simulation stud...

large quantities of radiopharmaceuticals prescribed for treatment and diagnosis are excreted through kidney. therefore, radiation unwanted dose is created in kidney. as a result, exact calculation of prescribed radiopharmaceuticals amount is important. monte carlo method is used for simulation of radiation transport in body due to random nature of radiation. in this research, for the first time...

large quantities of radiopharmaceuticals prescribed for treatment and diagnosis are excreted through kidney. therefore, radiation unwanted dose is created in kidney. as a result, exact calculation of prescribed radiopharmaceuticals amount is important. monte carlo method is used for simulation of radiation transport in body due to random nature of radiation. in this research, for the first time...

OBJECTIVE The carborane-containing porphyrin, copper (II) 2,3,7,8,12,13,17,18-octabromo-5,10,15,20-tetrakis(3-[1,2-dicarba-closo-dodecaboranyl]methoxyphenyl)-porphyrin (CuTCPBr), was investigated as a potential radiation enhancing agent for X-ray radiotherapy (XRT) in a subcutaneously implanted EMT-6 murine carcinoma. METHOD The biodistribution and toxicological profile of this porphyrin has ...