A ny discussion of psoriasis treatments must include the setting in which such treatments are administered. Traditionally these comprise in patient hospitalization, ambulatory day-care-center treatment such as with the Ingram or Goeckerman regimens, outpatient phototherapy with ultraviolet B (UVB) or with psoralen and ultraviolet A (PUVA), and home care under the supervision of a physician in a...

BACKGROUND Cutaneous lichen planus (CLP) is an inflammatory dermatosis. Its chronic relapsing course and frequently spontaneous regression hamper the assessment of treatment effectiveness. OBJECTIVE To evaluate the efficacy of available treatment modalities for CLP. DATA SOURCES PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov registry. METHODS We perfo...

Sir, Keratosis lichenoides chronica (KLC) is a rare and chronic skin disease characterized by erythemas, keratotic and lichenoid papules, arranged in a linear pattern (1) and seborrhoeic-like scaling lesions on the trunk and limbs (1, 2). The lesions are slowly progressive with no tendency to heal and are resistant to most therapeutic modalities. Typical locations are the limbs, face, nails, pa...

Hyperpigmented mycosis fungoides is an extremely rare subtype of mycosis fungoides. It presents as multiple pigmented macules and patches without poikilodermatous changes and characterized by a CD8+ phenotype on immunohistochemistry. This report describes a typical case of hyperpigmented mycosis fungoides in a 62-year-old woman, who presented with a 7-year history of multiple hyperpigmented mac...

Androgenetic alopecia and alopecia areata are common disorders of the hair follicle which may heavily influence self esteem and self image. Androgenetic alopecia is caused by the heightened sensitivity of scalp follicles to dihydro- testosterone whereas alopecia areata is induced by an autoimmune reaction. Current drug treatment approaches include the use of regrowth stimulators such as topical...

Starting at the end of 90’s, and derived from PUVA therapy, arose the concept of modulation of inappropriate immune conflicts by direct action of UVA on immunocompetent cells (lymphocytes, antigen processing cells). After the inactivation of T-cells in vitro and ex vivo, was demonstrated, the development step-by-step aimed to process large amounts of the so-called peripheral mononuclear cells. ...

BACKGROUND Various surgical procedures for correcting stable vitiligo exist but these have their own limitations. Autologous, non-cultured, non-trypsinized, melanocyte plus keratinocyte grafting is a new and simple method of vitiligo surgery. OBJECTIVE The study aimed to evaluate efficacy of a new grafting technique in vitiligo patches. METHODS Eighteen vitiligo patches underwent this proce...