نتایج جستجو برای: purkinje

تعداد نتایج: 7006  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
T Miyata K Nakajima K Mikoshiba M Ogawa

Cerebellar Purkinje cells are generated in the ventricular zone, migrate outward, and finally form a monolayer in the cortex. In reeler mice, however, most Purkinje cells cluster abnormally in subcortical areas. Reelin, the candidate reeler gene product recognized by the CR-50 monoclonal antibody, is concentrated in a cortical zone along which Purkinje cells are aligned linearly, implying that ...

Journal: :Journal of the American College of Cardiology 1993
H G Li D L Jones R Yee G J Klein

OBJECTIVES To understand the mechanisms of postdefibrillation arrhythmias and failed defibrillation, we studied the cellular effects of high voltage shocks on different cardiomyocytes in the dog. BACKGROUND The causes of postdefibrillation arrhythmias and unsuccessful defibrillation are not clear. METHODS High voltage shocks with voltage differentials of 9.3 to 97.6 V/cm were delivered to i...

2015
Melissa H. Kelley

...........................................................................................viii Abbreviations used in text....................................................................xi CHAPTER 1: General Introduction.........................................................1 I. Cardiac Arrest and Cerebral Ischemia............................................1 II. The Cerebellum and Purkin...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
E O'Hearn M E Molliver

Ibogaine, an indole alkaloid that causes hallucinations, tremor, and ataxia, produces cerebellar neurotoxicity in rats, manifested by degeneration of Purkinje cells aligned in narrow parasagittal bands that are coextensive with activated glial cells. Harmaline, a closely related alkaloid that excites inferior olivary neurons, causes the same pattern of Purkinje cell degeneration, providing a cl...

Journal: :Circulation research 1973
R Lazzara N el-Sherif B J Scherlag

Electrophysiological mechanisms which underlie the ectopic ventricular beats occurring 1 day after occlusion of the anterior descending coronary artery of dogs were explored. In intact dogs, bipolar electrograms were recorded in the infarcted and normal zones. Both Purkinje and ordinary myocardial potentials were recorded from the endocardial surface of the normal zone, but only Purkinje potent...

2009
Annarita de Luca Stefania Vassallo Beatriz Benitez-Temino Gianluca Menichetti Ferdinando Rossi Annalisa Buffo

BACKGROUND During development, neurons modify their axon growth mode switching from an elongating phase, in which the main axon stem reaches the target territory through growth cone-driven extension, to an arborising phase, when the terminal arbour is formed to establish synaptic connections. To investigate the relative contribution of cell-autonomous factors and environmental signals in the co...

2017
Pegah Afshar Niloufar Ashtari Xiaodan Jiao Maryam Rahimi-Balaei Xiaosha Zhang Behzad Yaganeh Marc R. Del Bigio Jiming Kong Hassan Marzban

The human superoxide dismutase 1 (SOD1) gene is responsible for neutralizing supercharged oxygen radicals within the cell. Mutation in SOD1 gene causes amyotrophic lateral sclerosis (ALS). Recent studies have shown involvement of the cerebellum in ALS, although the cerebellar contribution in SOD1 transgenic mice remains unclear. Using immunohistopathology, we investigated the Purkinje cell phen...

Journal: :The Journal of clinical investigation 1981
J C Somberg W H Barry T W Smith

The extent of inhibition of monovalent cation active transport in Purkinje fibers and myocardium in response to toxic and inotropic doses of digitalis were studied in the dog to elucidate the factors underlying the different relative sensitivities of these tissues to the toxic arrhythmogenic effects of digitalis. Monovalent cation transport inhibition was assessed by measuring uptake of the K(+...

Journal: :Brain, behavior and evolution 2015
Jeremy R Corfield Jeffery Kolominsky Gonzalo J Marin Iulia Craciun Bridget E Mulvany-Robbins Andrew N Iwaniuk Douglas R Wylie

Zebrin II (ZII) is a glycolytic enzyme expressed in cerebellar Purkinje cells. In both mammals and birds, ZII is expressed heterogeneously, such that there are sagittal stripes of Purkinje cells with a high ZII expression (ZII+) alternating with stripes of Purkinje cells with little or no expression (ZII-). To date, ZII expression studies are limited to neognathous birds: pigeons (Columbiformes...

Journal: :Neuroscience letters 1993
J V Rosenfeld L J Richards P F Bartlett

Embryonic cerebellum transplanted to adult Purkinje cell degenerate mice was assessed for integration and Purkinje cell migration by using the antigenic markers Thy-1 and Leu-4. It was found that the grafted cells migrated into the host's molecular layer, but there was no evidence for specific migration of Purkinje cells. Furthermore, grafted cells were found to form normal cerebellar cyto-arch...

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