BACKGROUND We tested the hypothesis that right ventricular (RV) pressure overload affects RV function and further influences left ventricular (LV) geometry, which adversely affects LV twist mechanics and segmental function. METHODS AND RESULTS Echocardiographic images were prospectively acquired in 44 patients (age, 46+/-12 years; 82% women) with evidence of pulmonary hypertension (estimated ...

DOI: 10.1164/rccm.2107027 Internet address: www.atsjournals.org In 120 patients with severe emphysema evaluated for participation in the National Emphysema Treatment Trial, pulmonary hemodynamics and ventricular function were assessed. Pulmonary function tests were (%predicted): FEV 1 27%; residual volume 224.6%; diffusion capacity 26.7%. In 90.8% of patients, endexpiratory pulmonary artery mea...

The effects of acute anoxia on pulmonary artery blood pressure, induced by breathing low oxygen (10 per cent 02 in N2) for short periods of time, have not been reported in man. Since acute anoxia is used extensively as a cardiac test and is frequently encountered in anesthesia, changes resulting in the pulmonary artery blood pressure should be of interest. METHODS. The influence of breathing 10...

Unilateral agenesis of the pulmonary artery is a rare congenital anomaly, which commonly involves the right side. Cases are associated with systemic collaterals, that may also rarely arise from the coronary arteries.Two adult patients are presented with a right pulmonary artery agenesis associated with collaterals from the right coronary artery. The implications of such an anomaly on pulmonary ...

Background—We tested the hypothesis that right ventricular (RV) pressure overload affects RV function and further influences left ventricular (LV) geometry, which adversely affects LV twist mechanics and segmental function. Methods and Results—Echocardiographic images were prospectively acquired in 44 patients (age, 46 12 years; 82% women) with evidence of pulmonary hypertension (estimated pulm...

T he ability to measure the hydrostatic pressure in a capillary bed (Pc) was an impetus for the development of the arterial occlusion method [1]. The relevance of Pc in pulmonary circulation is its role in pulmonary oedema formation. In order to accurately measure Pc, the isogravimetric method and the double occlusion technique have served as standards [2, 3]. However, both techniques require s...

Oxidative stress contributes to the development of pulmonary hypertension in experimental models, but this association in humans is unknown. We investigated the relationship between pulmonary artery systolic pressure measured by echocardiography and plasma aminothiol oxidative stress markers, with the hypothesis that oxidative stress will be higher in those with pulmonary hypertension. A group ...

A 51-year-old female undergoing an outpatient stress echocardiogram to evaluate atypical chest pain developed acute ST elevation in the anterior precordial leads on electrocardiogram following exercise. Echocardiography revealed a severe rise in pulmonary artery systolic pressure (PASP) with marked right ventricular (RV) enlargement and interventricular septum flattening. Subsequently, cardiac ...

Disproportionately high pulmonary artery pressures and pulmonary vascular resistance in acquired heart disease, particularly mitral stenosis, have been repeatedly observed. Seventeen patients with pulmonary hypertension secondary to elevated left atrial pressure have been studied by the method of temporary unilateral pulmonary artery occlusion: Resistances calculated before and after occlusion ...

artery occlusion caused no change in cardiac output, or right and left ventricular pressures, although right ventricular contractile force fell markedly. With right coronary artery flow intact, incremental pulmonary artery obstruction caused a corresponding decline in cardiac output and elevation of right ventricular end-diastolic pressure with eventual total right ventricular failure and syste...