Previous studies have shown that nitric oxide (NO) inhibits carotid body sensory activity. To begin to understand the cellular mechanisms associated with the actions of NO in the carotid body, we monitored the effects of NO donors on the macroscopic Ca2+ current in glomus cells isolated from rabbit carotid bodies. Experiments were performed on freshly dissociated glomus cells from adult rabbit ...

We have previously shown that NO•/cGMP signalling is an important antihyper-trophic mechanism in the heart [1-3]. HNO is the one electron reduction of NO•, thought to elicit cardiovascular actions via cGMP and/or calcitonin gene-related peptide (CGRP) [4]; we have recently shown that the HNO donor Angeli's salt inhibits cardiomyocyte hypertrophy and superoxide generation [5]. We now test the hy...

The reactive nitrogen species (RNS) nitric oxide (NO), nitroxyl anion (N0‘) and \ nitrosonium cation (NO+), modulate a myriad of biological processes. The microsomal haem oxygenases (HO-1, HO-2 and HO-3) oxidatively catabolise haem to bilirubin, carbon monoxide (CO) and ferrous iron (Fe2+). Sensitivity of the inducible isoform (HO-1) to a variety of inducers has identified HO-1 as an effective ...

xidative stress is a hallmark of cardiovascular diseases 1 and a major contributor to vascular dysfunction. 2 On the basis on recent concepts, vascular oxidative stress is caused mainly by infiltrating inflammatory cells such as monocytes/ macrophages or leucocytes, 3,4 producing so-called kindling radicals that lead to the activation of secondary, vascular enzymatic sources of reactive oxygen ...

BACKGROUND Nitric oxide (NO) attenuates neutrophil (PMN)-mediated damage, partly by inhibiting superoxide anion (O2-) generation and adherence to the coronary artery endothelium. L-Arginine is the endogenous substrate for production of NO via the NO synthase pathway. This study tested the hypothesis that the endogenous NO precursor L-arginine (L-Arg) would reduce PMN-induced coronary artery dys...

1. A few studies have shown that nitric oxide may exert cytotoxic and/or steroidogenic effects on cultured ovarian cells but the source of this factor within the ovary remains equivocal. 2. In this study we have investigated the effects of nitric oxide on progesterone secretion, cell viability and cell morphology of cultured rat granulosa/lutein cells and examined whether granulosa cells are an...

The term cortical spreading depolarization (CSD) describes a wave of mass neuronal depolarization associated with net influx of cations and water. Clusters of prolonged CSDs were measured time-locked to progressive ischaemic damage in human cortex. CSD induces tone alterations in resistance vessels, causing either transient hyperperfusion (physiological haemodynamic response) in healthy tissue;...

Summers, Beth A., Jeffrey L. Overholt, and Nanduri R. Prabhakar. Nitric oxide inhibits L-type Ca current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism. J. Neurophysiol. 81: 1449–1457, 1999. Previous studies have shown that nitric oxide (NO) inhibits carotid body sensory activity. To begin to understand the cellular mechanisms associated with the actions of NO in th...

See Article page e90.Central MessagePreventing spinal cord deficit requires a multimodal approach. e90. Preventing Although open aortic repair is associated with substantial postoperative complications, (ie, paraplegia and paraparesis) may be the most devastating one. Regarding Crawford's lifetime experience 1509 thoracoabdominal aneurysm (TAAA) repairs, as presented in late 1990s by Svensson c...

The present study underlines the importance of gemfibrozil, a lipid-lowering drug and an activator of peroxisome proliferatoractivated receptor(PPAR), in inhibiting the disease process of adoptively transferred experimental allergic encephalomyelitis (EAE), an animal model of relapsing-remitting multiple sclerosis. Clinical symptoms of EAE, infiltration of mononuclear cells, and demyelination w...