نتایج جستجو برای: protein tyrosine phosphatase 1b

تعداد نتایج: 1300053  

Journal: :The Biochemical journal 1997
F Liu J Chernoff

We used a substrate-trapping technique to search for substrates of protein tyrosine phosphatase (PTP) 1B. A catalytically inactive form of this enzyme forms a stable, phosphotyrosine-dependent complex with epidermal growth factor receptor (EGFR) both in vitro and in cells. PTP1B also interacts with activated platelet-derived growth factor receptor (PDGFR) but not with colony-stimulating factor ...

2017
Jia-Yu Liu Song Mu Shu-Ping Zhang Wei Guo Qi-Fu Li Xiao-Qiu Xiao Jun Zhang Zhi-Hong Wang

The present study aimed to explore the effect of Roux-en-Y gastric bypass (RYGB) surgery on protein tyrosine phosphatase 1B (PTP1B) expression levels and leptin activity in hypothalami of obese rats. Obese rats induced by a high-fat diet (HFD) that underwent RYGB (n=11) or sham operation (SO, n=9), as well as an obese control cohort (Obese, n=10) and an additional normal-diet group (ND, n=10) w...

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