Background: Oral contraceptive pills are commonly used in the treatment of PCOS; but, their influence on metabolic parameters is not well known. Metformin, a biguanide antihyperglycemic drug, has been shown to improve ovarian function and glucose metabolism in women with polycystic ovary syndrome (PCOS), but results concerning its effects

Aim: The association between oxidative stress and diabetic complications is well known. The main goal of antidiabetic therapy is to prevent the complications of diabetes. Gliclazide (sulfonylurea) and metformin (biguanide) are two oral antidiabetic drugs that have been proven to prevent diabetic complications. In this study, we aimed to investigate the antioxidant effects of gliclazide or metfo...

Metformin, an oral anti-diabetic drug, is being considered increasingly for treatment and prevention of cancer, obesity as well as for the extension of healthy lifespan. Gradually accumulating discrepancies about its effect on cancer and obesity can be explained by the shortage of randomized clinical trials, differences between control groups (reference points), gender- and age-associated effec...

Ultraviolet and heat-curable polyurethane acrylate prepolymers were synthesized from 4,4’-diphenyl methane diisocyanate, polyethylene adipate diol, polyhexamethylene carbonate diol, polycaprolactone diol and 1,6hexamethylene diamine , acrylic acid. Effects of nature of the soft segments on the physical properties were investigated. It was found that the thermal stability increased from polycarb...

The biguanide metformin has been safely and widely used in the treatment of type 2 diabetes mellitus for decades. Preclinical studies have suggested that it may a role slowing disease progression autosomal dominant polycystic kidney disease. In this issue, Perrone et al. report results from Trial Administration Metformin PKD (TAME PKD) study, phase randomized controlled trial investigati...