نتایج جستجو برای: plc gene

تعداد نتایج: 1146437  

2016
Guo-Chao Zhong Yan Liu Yuan-Yuan Ye Fa-Bao Hao Kang Wang Jian-Ping Gong

A protective effect of statins on primary liver cancer (PLC) risk has been suggested. However, issues about the dose-response relationship, the protective effect of individual statins, and PLC risk reduction among at-risk populations remain unsolved. Therefore, a meta-analysis was conducted. PubMed and EMBASE were searched for studies providing the risk ratio (RR) on statins and PLC risk. Summa...

Journal: :Biochemical and biophysical research communications 1996
Z Pei L Yang J R Williamson

Association of phospholipase C (PLC)-gamma 1 with the cytoskeleton has been postulated to be one of the crucial steps for PLC-gamma 1 activation and translocation to the plasma membrane. In this report, direct binding assays were carried out to study which fragment of PLC-gamma 1 Src homology region has been able to bind to the actin-cytoskeleton. Using GST fusion proteins containing various de...

2015
Alberto Sendin Txetxu Arzuaga Iker Urrutia Iñigo Berganza Ainara Fernandez Laura Marron Asier Llano Aitor Arzuaga Thorsten Staake

Powerline communications (PLC)-based smart meter deployments are now a reality in many regions of the world. Although PLC elements are generally incorporated in smart meters and data concentrators, the underlying PLC network allows the integration of other smart grid services directly over it. The remote control capabilities that automation programs need and are today deployed over their medium...

2015
Seong-Wook Kim Taesup Cho Sukchan Lee

Schizophrenia is a mental disorder that is characterized by various abnormal symptoms. Previous studies indicate decreased expression of phospholipase C-β1 (PLC-β1) in the brains of patients with schizophrenia. PLC-β1-null (PLC-β1(-/-)) mice exhibit multiple endophenotypes of schizophrenia. Furthermore, a study of PLC-β1 knockdown in the medial prefrontal cortex of mice has shown a specific beh...

Journal: :Developmental biology 2007
Jun Wang Linda Mayernik D Randall Armant

Integrin signaling modulates trophoblast adhesion to extracellular matrices during blastocyst implantation. Fibronectin (FN)-binding activity on the apical surface of trophoblast cells is strengthened after elevation of intracellular Ca(2+) downstream of integrin ligation by FN. We report here that phosphoinositide-specific phospholipase C (PLC) mediates Ca(2+) signaling in response to FN. Phar...

2012
Yoshiko Niibori Theresa M. Filtz

approved: Theresa M. Filtz Long-term stimuli of many systems leads to decreased cellular responsiveness, or desensitization. We characterized the desensitization of angiotensin II (Ang 11)-mediated inositol phospholipid (IP) hydrolysis in cultured human aortic smooth muscle cells (HASMC). Although it has been suggested that the desensitization induced by long-term Mg II exposure may result part...

Journal: :The Journal of General Physiology 2005
Lisa F. Horowitz Wiebke Hirdes Byung-Chang Suh Donald W. Hilgemann Ken Mackie Bertil Hille

We have further tested the hypothesis that receptor-mediated modulation of KCNQ channels involves depletion of phosphatidylinositol 4,5-bisphosphate (PIP2) by phosphoinositide-specific phospholipase C (PLC). We used four parallel assays to characterize the agonist-induced PLC response of cells (tsA or CHO cells) expressing M1 muscarinic receptors: translocation of two fluorescent probes for mem...

Journal: :International journal of molecular medicine 2005
Alan J Stewart Joy Mukherjee Scott J Roberts Douglas Lester Colin Farquharson

Phosphoinositol (PhoIns)-specific phospholipase C enzymes (PLCs) are central to the inositol lipid signaling pathways and contribute to intracellular Ca2+ release and protein kinase C activation. Five distinct classes of PhoIns-specific PLCs are known to exist in mammals, which are activated by membrane receptor-mediated events. Here we have identified a sixth class of PhoIns-specific PLC with ...

Journal: :Int. Journal of Network Management 2006
Jae-Jo Lee Choong Seon Hong Joon-Myung Kang James Won-Ki Hong

Power line communication (PLC) has become an important network access technology to conveniently and effectively provide various useful services such as remote meter reading, broadband Internet access, and home networking services. As the deployment and use of PLC networks increase, it is essential that we need to be able to configure, monitor, and control the PLC network resources. In this pap...

2015
Matteo Giorgi-Pierfranceschi Pierpaolo Di Micco Chiara Cattabiani Anna Guida Barbara Pagán Maria del Valle Morales Estuardo Salgado José Maria Suriñach Carles Tolosa Manuel Monreal

The outcome of patients with acute venous thromboembolism (VTE) and abnormal platelet count (PlC) at baseline has not been consistently studied. In real-world clinical practice, a number of patients with abnormal PlC receive vitamin K antagonists (VKAs) to treat acute VTE despite their higher risk of bleeding.We used the Registro Informatizado de Enfermedad TromboEmbólica registry database to c...

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