A peptic ulcer in a child looks the same as it does in an adult, and many of the aetiologies of peptic ulcer disease in children are similar to those in adults. However, there are many differences between children and adults, especially in the areas of clinical presentation, the prevalences of different types of ulcer disease, and the prevalence of complications of ulcer disease. Therefore the ...

Helicobacter pylori causes human gastroduodenal diseases, including chronic gastritis and peptic ulcer disease. It is also a major microbial risk factor for the development of gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Twenty-one strains with different ethnicity, disease, and antimicrobial susceptibility backgrounds were sequenced by use of Illumina HiSeq and ...

Acid-related disorders include not only reflux esophagitis and peptic ulcer, but also a subset of patients with endoscopy-negative dyspepsia. The management strategy differs between these diseases and therefore a precise diagnosis is important. The unaided clinical diagnosis is of limited value in patients with pain or discomfort in the upper abdomen, and endoscopy is therefore an important and...

INTRODUCTION During the past century, gastroenterologists have experienced major shifts in the occurrence of several common diseases affecting the digestive tract. The historic fall in the occurrence of gastric cancer and peptic ulcer disease during the twentieth century was accompanied by a simultaneous rise in the occurrence of inflammatory bowel disease and gastroesophageal reflux disease du...

BACKGROUND Upper gastrointestinal (GI) diseases are common, but there is a paucity of data describing variations by ethnic group and so a lack of understanding of potential health inequalities. We studied the incidence of specific upper GI hospitalization and death by ethnicity in Scotland. METHODS Using the Scottish Health and Ethnicity Linkage Study, linking NHS hospitalizations and mortali...

Perforation is a life-threatening complication of peptic ulcer disease. Smoking and use of non-steroidal anti-inflammatory drugs are important risk factors for perforation. Diagnosis is made clinically and confirmed by the presence of pneumoperitoneum on radiographs. Nonoperative management is successful in patients identified to have a spontaneously sealed perforation proven by water-soluble c...

Peptic ulcer disease is usually diagnosed on the basis of well recognised symptoms confirmed by endoscopy or barium study. Within the community an unknown number of people, however, may have peptic ulcer disease without symptoms, some of whom present only because of haemorrhage or perforation. Roughly a third of the cases of perforated peptic ulcer, for example, occur in people without any prev...

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