Hematologic malignancy is a risk factor for severe coronavirus disease 2019 (COVID-19) in adults; however, data specific to children with leukemia are limited. High-quality infectious adverse event from the ongoing Children's Oncology Group (COG) standard-risk B acute lymphoblastic leukemia/lymphoma (ALL/LLy) trial, AALL1731, were analyzed provide disease-specific estimate of SARS-CoV-2 infecti...

Summary Leukemia and lymphoma are a leading cause of cancer-related mortality in children the prognosis for patients with relapsed or refractory disease remains poor. Standard therapies associated wide array acute long-term toxicities. Immunotherapy is changing treatment landscape pediatric leukemia has advanced at tremendous pace over last decade. Immunotherapies thought to exhibit fewer toxic...

Department of Hematology, Oncology and Palliative Care, Klinikum Stuttgart, Stuttgart, Germany; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA; Unit of Lymphoid Malignancies, Department of Onco-Hematology, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy; Division of Hematology/Oncology, San Francisco Helen Diller ...

Primary ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphomas (OAMLs) are mostly seen in the 5th-7th decades of life, with female predominance, and they occur rarely in children. Thus, knowledge about this cancer type is obtained from adult data in the literature, while the data regarding OAMLs in the pediatric population are limited to a few case reports. Herein, we report a 10-yea...

*Damien Roos-Weil,1 *Sascha Dietrich,2,3 Ariane Boumendil,3 Emmanuelle Polge,4 Dominique Bron,5 Enric Carreras,6 Arturo Iriondo Atienza,7 William Arcese,8 Dietrich W. Beelen,9 Jan J. Cornelissen,10 Nicolaus Kröger,11 Giuseppe Milone,12 Giuseppe Rossi,13 Fabrice Jardin,14 Christina Peters,15 Vanderson Rocha,16 Anna Sureda,17 Mohamad Mohty,18 and Peter Dreger,2,3 on behalf of the European Group f...

Follicular lymphoma (FL) is a heterogeneous disease, and there are many different subgroups, such as in terms of age of onset, involved organ (especially extranodal sites such as gastrointestinal tract) and genetic abnormality. Grade 3B is currently regarded as a distinct entity by molecular genetic analyses, but the independence of Grade 3A remains unclear. Variations of clinical course are kn...

The cancer datasets used in this study (dbGaP: phs000341.v2.p1 and phs000340.v3.p1; EBI: EGAS00001000399) were generated with the financial support of the National Cancer Institute, the St. Baldrick’s Foundation, Partners for Cures, the American Lebanese Syrian Associated Charities of St. Jude Children’s Research Hospital as part of the St. Jude/Washington University Pediatric Cancer Genome Pro...

Describe the types of malignancies commonly 1. found in children and adolescents with human immunodeficiency virus (HIV)/AIDS. Present an overview of the following HIV2. associated pediatric and adolescent cancers: nonHodgkin’s lymphoma (NHL), Kaposi sarcoma (KS), leiomyosarcoma, cervical carcinoma, and anal cancer. Discuss the clinical manifestations and treatment 3. of the various HIV-associa...