BACKGROUND Fever and neutropenia (FN) often complicate anticancer treatment and can be caused by potentially fatal infections. Knowledge of pathogen distribution is paramount for optimal patient management. METHODS Microbiologically defined infections (MDI) in pediatric cancer patients presenting with FN by nonmyeloablative chemotherapy enrolled in a prospective multicenter study were analyze...

Currently, the characteristics of emergence and course burnout syndrome among medical staff working with cancer children are not studied enough. It seems relevant to consider psychological features oncological specialists as an important personal factor, a protector syndrome. The (empathetic tendencies, situational anxiety, neurotization, self-actualization) in health care professionals were in...

This descriptive study was conducted to determine the validity and reliability in Turkey of the Pediatric Quality of Life Inventory Cancer Module (PedsQL 3.0) for children aged 8-12 in the hematology-oncology polyclinics of two university hospitals in Istanbul during the period 2006-2007. The data collection instruments were the Pediatric Quality of Life Inventory (PedsQL 4.0), the Pediatric Qu...

Aims: to identify the reactions of relatives after a diagnosis of pediatric cancer; to describe the work of the nursing team based on these reactions; to analyze the expectation of the family regarding nursing care based on the diagnosis of pediatric cancer. Method: this is a qualitative, descriptive research performed in an onco-hematologic ward located in the state of Rio de Janeiro, Brazil. ...

The American Association for Cancer Research convened a meeting of international pediatric oncologists, geneticists, genetic counselors, and radiologists expert in childhood cancer predisposition syndromes (CPS) in October 2016 to propose consensus surveillance guidelines. Imaging plays a central role in surveillance for most, though not all, syndromes discussed. While encompassing the full gam...

Multiagent chemotherapy, radiotherapy, or a combination of both are the contemporary methods of cancer treatment. With medical advancements, though cure rates have increased considerably, focus is now shifted to the potential early and late complications of the same. The aim of this study was to assess the early oral complications in pediatric patients receiving chemotherapy. Sixty-two children...

This article presents an analysis of issues related to low-dose radiation, with a focus on pediatric computed tomography (CT). It references several early studies that are seldom quoted in radiation research papers, then quantifies the excess lifetime fatal cancer yield attributable to an estimated 6.5 million pediatric abdominal CT scans. The authors highlight an important policy document issu...

The glutathione S-transferases (GSTs) are a family of ubiquitously expressed polymorphic enzymes important for detoxifying endogenous and exogenous compounds. In addition to their classic activity of detoxification by conjugation of compounds with glutathione, many other functions are now found to be associated with GSTs. The associations between GST polymorphisms/functions and human disease su...

St. Jude Children’s Research Hospital is the first and only NCIdesignated Comprehensive Cancer Center devoted solely to children. Since opening 55 years ago, St. Jude Children’s Research Hospital has played a pivotal role in increasing overall US pediatric cancer survival rates from 20% to 80%. St. Jude gained international attention within the first decade of its opening with groundbreaking re...

BACKGROUND Professionals treating adolescents with cancer must communicate well with them and their parents. Evidence suggests that the communication needs of this population are rarely met. Skills training can improve professional communication, but has been criticized for not being based on the experience of the participants in the clinical encounter. We took a multiperspective approach, draw...