On five commercial cattle rearing sites across Europe, a total of 802 young cattle at high risk of developing bovine respiratory disease (BRD) associated with the bacterial pathogens Mannheimia haemolytica or Pasteurella multocida and/or Mycoplasma bovis were enrolled into a multicentre, controlled field trial. Half were treated with a single dose of gamithromycin at 6 mg/kg bodyweight by subcu...

Bovine respiratory disease (BRD) is a complex, multifactorial syndrome and one of the major welfare economical concerns for cattle industry. This 1-year cross-sectional study was aimed at documenting prevalence BRD-related pathogens clinical signs before after long journey identifying possible predisposition factors. Male Limousine beef steers ( n = 169) traveling from France to Italy were heal...

Pasteurella haemolytica is an important respiratory pathogen of cattle that incites extensive infiltrates of neutrophils into the lung. In addition to the parenchymal damage caused by factors released by P. haemolytica, neutrophils contribute to the pathologic changes in the lungs. Molecules which mediate neutrophil infiltration into the lungs during P. haemolytica pneumonia are poorly characte...